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Table 1 Cardamonin inhibited ATP production and the activity of HK and LDH

From: Glycolysis inhibition via mTOR suppression is a key step in cardamonin-induced autophagy in SKOV3 cells

  ATP (μmoL/g prot) HK (U/g prot) LDH (U/g prot)
Control 94.05 ± 0.94 43.63 ± 3.82 307.28 ± 6.71
Cardamonin (5 μM) 87.69 ± 0.79** 35.58 ± 3.34** 292.94 ± 5.56**
Cardamonin (10 μM) 50.98 ± 1.67** 33.95 ± 3.04** 276.62 ± 4.04**
Cardamonin (20 μM) 29.87 ± 1.31** 27.46 ± 3.60** 225.58 ± 7.50**
Rapamycin (0.1 μM) 56.07 ± 1.47** 34.14 ± 4.90** 286.46 ± 8.68**
2-DG (10 mM) 24.33 ± 1.90** 43.72 ± 3.12 302.43 ± 4.20
  1. SKOV3 cells were treated with cardamonin (5, 10, 20 μM), rapamycin (0.1 μM) and 2-DG (10 mM) for 48 h, respectively. ATP content and the activity of HK and LDH were analyzed by the assay kits, respectively. **p < 0.01 compared to control. Data were represented as mean ± SD, n = 6
  2. 2-DG 2-deoxy-D-glucose, HK hexokinase, LDH lactate dehydrogenase