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Table 4 Correlation between phytochemical content, antioxidant, anti-inflammatory and antiproliferative activity of active extracts

From: Croton gratissimus leaf extracts inhibit cancer cell growth by inducing caspase 3/7 activation with additional anti-inflammatory and antioxidant activities

Cell lines

Pearson correlation coefficient (r)

TPC

TFC

DPPH

ABTS

NO

15-LOX

A549

0.3530

0.2404

0.2850

0.4030

0.2525

0.1935

Caco-2

0.0143

0.4529

0.4545

0.2758

0.2820

0.2798

HeLa

0.0920

0.3724

0.3582

0.2043

0.2847

0.2251

MCF-7

0.3111

0.2399

0.0800

0.0003

0.2027

0.2341

  1. Correlation coefficients were determined by plotting a linear curve with IC50 values of extracts obtained for each cancer cell on the y-axis against the corresponding phytochemical content or IC50 values of the antioxidant power (DPPH, ABTS) and anti-inflammatory activity (NO, 15-LOX) on the x-axis. NO: nitric oxide, 15-LOX: 15-lipoxygenase. TPC: total phenolic content, TFC: total flavonoid content, DPPH: 2,2-diphenyl-1-picrylhydrazyl radical, ABTS: 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical