BMC Complementary Medicine and Therapies

Table 5 Histopathology and histomorphometry of the femur in sham-operated and OVX mice: Cortical Bones and Osteoclast Cells

From: Anti-osteoporotic effects of mixed compositions of extracellular polymers isolated from Aureobasidium pullulans and Textoria morbifera in ovariectomized mice

Items Groups	Left femur tissues
Items Groups	Cbt	Ocn	OS/BS
Controls
Sham	305.93 ± 46.58	3.00 ± 1.31	3.70 ± 1.94
OVX	171.11 ± 17.15^a	19.63 ± 2.50^a	25.29 ± 6.10^a
Reference (2.5 mg/kg)
RES	170.51 ± 11.52^a	20.25 ± 4.53^a	10.09 ± 1.86^ab
Single formula (200 mg/kg)
EAP	196.82 ± 12.34^ab	13.88 ± 2.36^ab	15.53 ± 2.37^ab
TM	188.84 ± 9.85^ac	13.13 ± 2.10^ab	14.48 ± 3.30^ab
Mixed formula - EAP:TM (200 mg/kg)
1:1	195.02 ± 9.43^ab	13.50 ± 1.77^ab	15.20 ± 1.71^ab
1:3	191.78 ± 9.42^ac	13.25 ± 3.15^ab	14.79 ± 4.39^ab
1:5	189.98 ± 8.23^ac	13.75 ± 1.91^ab	16.18 ± 1.78^ab
1:7	190.90 ± 7.34^ac	12.50 ± 2.45^ab	14.86 ± 2.38^ab
1:9	190.56 ± 10.85^ac	13.13 ± 1.73^ab	14.93 ± 2.49^ab
3:1	236.15 ± 33.30^abde	6.63 ± 1.41^abde	7.18 ± 1.41^abde
5:1	194.38 ± 10.32^ab	12.50 ± 1.60^ab	13.91 ± 2.35^ab
7:1	194.87 ± 10.65^ab	12.25 ± 2.71^ab	14.02 ± 3.30^ab
9:1	196.31 ± 10.93^ab	13.25 ± 2.05^ab	15.14 ± 1.73^ab

OVX Bilateral ovariectomy, RES Risedronate sodium, EAP Exopolymers purified from A. pullulans SM2001, TM T. morbifera leaf extracts, (EAP:TM) Mixed formula consisted of EAP and TM (g/g), Cbt Cortical bone thickness (Cross thickness; μm), Ocn Osteoclast cell number (Numbers/epiphyseal), OS/BS Osteoclast cell surface/bone surface (%)
Values are expressed mean ± S.D. of eight mice
^ap < 0.01 as compared with sham control by MW test
^bp < 0.01 and ^cp < 0.05 as compared with OVX control by MW test
^dp < 0.01 as compared with EAP single formula treated mice by MW test
^ep < 0.01 as compared with TM single formula treated mice by MW test

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ISSN: 2662-7671

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