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Table 5 Cytotoxic activity of the isolated compounds

From: Study of the anti-allergic and anti-inflammatory activity of Brachychiton rupestris and Brachychiton discolor leaves (Malvaceae) using in vitro models

Cell line

Conc. (μg/mL)

% Inhibition

β-amyrin acetate (1)

Scopoletin (4)

HepG2

20

12.1 ± 3.4

11.4 ± 2.1

10

16.0 ± 0.3

6.5 ± 1.2

5

20.4 ± 2.3

0.9 ± 0.1

2.5

8.23 ± 0.7

5.9 ± 1.2

MDA-MB-231

20

−19.6 ± 1.2

8.2 ± 1.0

10

−13.9 ± 1.2

6.0 ± 0.3

5

−5.5 ± 1.2

10.7 ± 9.8

2.5

7.0 ± 0.1

15.5 ± 0.3

A549

20

2.2 ± 0.5

7.9 ± 0.4

10

9.0 ± 1.0

14.9 ± 0.4

5

10.8 ± 0.5

14.6 ± 0.5

2.5

0.4 ± 0.7

14.3 ± 0.7

  1. Results are presented as cell growth inhibition percentage at concentrations of 2.5 to 20 μg/mL, mean ± SD (n = 3). Doxorubicin was used as the positive control and exerted significant cell viability inhibitory effects against HepG2 (IC50 0.49 μg/mL), MDA-MB-231 (IC50 0.68 μg/mL)