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Table 2 Anti-allergic activity of B. rupestris and B. discolor extracts and fractions

From: Study of the anti-allergic and anti-inflammatory activity of Brachychiton rupestris and Brachychiton discolor leaves (Malvaceae) using in vitro models

Sample

% viability, RBL-2H3a

% inhibition of A23187-induced β-hexosaminidase releaseb

100 μg/mL

10 μg/mL

100 μg/mL

BRT

99.0 ± 1.7

3.0 ± 5.2

25.7 ± 2.1**

BRH

96.7 ± 4.0

3.3 ± 5.8

39.0 ± 13.1**

BRD

95.3 ± 8.1

4.3 ± 7.5

19.0 ± 4.4*

BRE

97.7 ± 4.0

2.0 ± 3.5

7.0 ± 5.2

BRR

99.0 ± 1.7

4.3 ± 5.1

3.7 ± 6.4

BDT

99.0 ± 1.7

3.7 ± 6.4

16.0 ± 5.0*

BDH

99.7 ± 0.6

4.3 ± 7.5

30.3 ± 3.1**

BDD

100.0 ± 0.0

0.0 ± 0.0

44.0 ± 7.8**

BDE

100.0 ± 0.0

1.7 ± 2.9

0.3 ± 0.6

  1. aThe cytotoxicity of samples towards RBL-2H3 cells was evaluated using MTT viability assay and none of the samples showed any toxicity; results are presented as mean ± SD (n = 3)
  2. bDexamethasone (10 nM) was used as the positive control and inhibited 62.0 ± 9.5%** of A23187-induced β-hexosaminidase release in RBL-2H3 cells. Results are presented as mean ± SD (n = 3); *p < 0.05, **p < 0.001 compared with the control value (A23187 only)
  3. BRT B. rupestris total methanol extract, BRH B. rupestris n-hexane fraction, BRD B. rupestris dichloromethane fraction, BRE B. rupestris ethyl acetate fraction, BRR B. rupestris remaining MeOH(aq) fraction, BDT B. discolor total methanol extract, BDH B. discolor n-hexane fraction, BDD B. discolor dichloromethane fraction, BDE B. discolor ethyl acetate fraction