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Table 4 The concentrations (ng/mL) of MON and DA in various tissues after oral administration of 100 mg/kg MOIG in female rats (mean ± SD, n = 3)

From: Pharmacokinetics and tissue distribution of monotropein and deacetyl asperulosidic acid after oral administration of extracts from Morinda officinalis root in rats

Tissue/organs Component 0.5 h 1 h 2 h 4 h 8 h 12 h 24 h
Small intestine MON 244.3 ± 392.8 19,223.7 ± 9918.4 11,552.4 ± 18,012.3 5751.1 ± 4091.9 26.1 ± 20.4 8.3 ± 14.4 1.9 ± 3.2
DA 153.0 ± 232.2 11,548.8 ± 3298.3 7897.3 ± 11,589.7 6001.6 ± 2129.6 28.3 ± 10.9 198.7 ± 310.3 3.0 ± 5.2
Large intestine MON 966.5 ± 1501.4 1089.2 ± 411.5 2949.1 ± 4063.5 215.6 ± 137.4 27.9 ± 5.8 17.4 ± 22.5 0.0 ± 0.0
DA 1408.8 ± 2274.2 2026.4 ± 1904.6 5383.1 ± 4417.7 5200.8 ± 4470.2 246.3 ± 189.6 374.1 ± 418.7 0.4 ± 0.3
Stomach MON 1913.2 ± 1817.5 3098.1 ± 3293.7 1226.6 ± 1009.2 39.1 ± 22.2 81.3 ± 25.5 0.0 ± 0.00 0.0 ± 0.0
DA 1526.7 ± 1436.1 3015.9 ± 3232.2 1328.7 ± 1031.1 83.0 ± 33.6 73.6 ± 22.8 1.0 ± 0.9 0.0 ± 0.0
Spleed MON 25.0 ± 16.2 102.8 ± 120.3 28.5 ± 21.9 7.7 ± 7.1 14.9 ± 22.5 0.0 ± 0.0 0.0 ± 0.0
DA 29.4 ± 15.7 83.9 ± 82.6 43.6 ± 31.6 19.9 ± 11.5 16.5 ± 17.7 0.0 ± 0.0 0.0 ± 0.0
Ovary MON 374.7 ± 318.2 2112.7 ± 2497.3 504.0 ± 470.3 138.4 ± 105.5 45.5 ± 15.6 6.5 ± 11.3 1.7 ± 2.9
DA 241.9 ± 185.0 854.1 ± 859.3 382.3 ± 298.2 110.4 ± 101.8 33.8 ± 9.5 5.7 ± 9.8 0.7 ± 1.3
Uterus MON 331.7 ± 229.3 2214.1 ± 2264.0 601.3 ± 664.6 269.9 ± 217.3 97.2 ± 21.0 0.0 ± 0.0 3.0 ± 5.0
DA 194.0 ± 122.7 1069.7 ± 908.8 426.3 ± 422.7 256.6 ± 340.3 68.4 ± 14.9 1.8 ± 2.1 3.6 ± 3.5
Heart MON 44.3 ± 18.2 79.0 ± 91.0 21.5 ± 3.6 5.8 ± 5.7 3.7 ± 6.5 0.0 ± 0.0 0.0 ± 0.0
DA 45.8 ± 19.1 86.1 ± 81.8 42.1 ± 7.7 17.6 ± 4.9 6.3 ± 5.6 0.0 ± 0.0 0.0 ± 0.0
Kidney MON 146.6 ± 133.3 139.8 ± 98.6 68.3 ± 25.4 48.8 ± 27.5 14.1 ± 10.3 0.0 ± 0.0 8.1 ± 14.0
DA 1832.9 ± 2990.7 218.6 ± 114.6 264.8 ± 33.7 244.0 ± 25.8 109.0 ± 22.5 44.6 ± 2.5 0.9 ± 1.4
Marrow MON 583.1 ± 978.7 257.0 ± 226.1 48.4 ± 60.3 10.7 ± 14.8 0.1 ± 0.2 0.0 ± 0.0 0.0 ± 0.0
DA 446.2 ± 744.7 209.9 ± 183.6 66.1 ± 51.3 27.6 ± 29.1 3.8 ± 1.9 0.0 ± 0.0 0.0 ± 0.0
Liver MON 729.3 ± 993.8 169.0 ± 129.8 66.4 ± 23.4 13.9 ± 4.6 33.0 ± 36.6 0.0 ± 0.0 0.0 ± 0.0
DA 536.2 ± 725.7 142.0 ± 83.4 87.2 ± 13.9 42.2 ± 12.1 36.3 ± 14.4 3.1 ± 3.0 0.0 ± 0.0
Lung MON 72.2 ± 53.3 398.3 ± 491.2 50.6 ± 33.7 244.8 ± 407.7 26.7 ± 25.6 47.6 ± 82.5 0.0 ± 0.0
DA 56.5 ± 29.8 222.3 ± 257.4 72.1 ± 28.2 180.7 ± 267.3 23.8 ± 16.9 30.2 ± 52.3 0.0 ± 0.0
Thymus MON 22.3 ± 9.2 140.0 ± 144.2 32.6 ± 36.1 1.8 ± 1.1 22.8 ± 6.3 0.0 ± 0.00 0.0 ± 0.0
DA 26.50 ± 7.7 136.05 ± 128.2 57.3 ± 45.6 14.1 ± 3.4 30.6 ± 8.6 0.0 ± 0.0 0.0 ± 0.0
Hypothalamus MON 2209.3 ± 3684.2 504.1 ± 333.9 226.2 ± 264.4 41.1 ± 43.2 72.3 ± 95.2 0.0 ± 0.0 9.7 ± 16.9
DA 1754.0 ± 2942.7 287.1 ± 176.9 145.8 ± 144.6 47.2 ± 9.2 67.7 ± 77.7 0.0 ± 0.0 21.0 ± 36.4