Pharmacokinetics and tissue distribution of monotropein and deacetyl asperulosidic acid after oral administration of extracts from Morinda officinalis root in rats

Shen, Yi; Zhang, Qi; Wu, Yan-bin; He, Yu-qiong; Han, Ting; Zhang, Jian-hua; Zhao, Liang; Hsu, Hsien-yeh; Song, Hong-tao; Lin, Bing; Xin, Hai-liang; Qi, Yun-peng; Zhang, Qiao-yan

doi:10.1186/s12906-018-2351-1

Table 4 The concentrations (ng/mL) of MON and DA in various tissues after oral administration of 100 mg/kg MOIG in female rats (mean ± SD, n = 3)

From: Pharmacokinetics and tissue distribution of monotropein and deacetyl asperulosidic acid after oral administration of extracts from Morinda officinalis root in rats

Tissue/organs	Component	0.5 h	1 h	2 h	4 h	8 h	12 h	24 h
Small intestine	MON	244.3 ± 392.8	19,223.7 ± 9918.4	11,552.4 ± 18,012.3	5751.1 ± 4091.9	26.1 ± 20.4	8.3 ± 14.4	1.9 ± 3.2
Small intestine	DA	153.0 ± 232.2	11,548.8 ± 3298.3	7897.3 ± 11,589.7	6001.6 ± 2129.6	28.3 ± 10.9	198.7 ± 310.3	3.0 ± 5.2
Large intestine	MON	966.5 ± 1501.4	1089.2 ± 411.5	2949.1 ± 4063.5	215.6 ± 137.4	27.9 ± 5.8	17.4 ± 22.5	0.0 ± 0.0
Large intestine	DA	1408.8 ± 2274.2	2026.4 ± 1904.6	5383.1 ± 4417.7	5200.8 ± 4470.2	246.3 ± 189.6	374.1 ± 418.7	0.4 ± 0.3
Stomach	MON	1913.2 ± 1817.5	3098.1 ± 3293.7	1226.6 ± 1009.2	39.1 ± 22.2	81.3 ± 25.5	0.0 ± 0.00	0.0 ± 0.0
Stomach	DA	1526.7 ± 1436.1	3015.9 ± 3232.2	1328.7 ± 1031.1	83.0 ± 33.6	73.6 ± 22.8	1.0 ± 0.9	0.0 ± 0.0
Spleed	MON	25.0 ± 16.2	102.8 ± 120.3	28.5 ± 21.9	7.7 ± 7.1	14.9 ± 22.5	0.0 ± 0.0	0.0 ± 0.0
Spleed	DA	29.4 ± 15.7	83.9 ± 82.6	43.6 ± 31.6	19.9 ± 11.5	16.5 ± 17.7	0.0 ± 0.0	0.0 ± 0.0
Ovary	MON	374.7 ± 318.2	2112.7 ± 2497.3	504.0 ± 470.3	138.4 ± 105.5	45.5 ± 15.6	6.5 ± 11.3	1.7 ± 2.9
Ovary	DA	241.9 ± 185.0	854.1 ± 859.3	382.3 ± 298.2	110.4 ± 101.8	33.8 ± 9.5	5.7 ± 9.8	0.7 ± 1.3
Uterus	MON	331.7 ± 229.3	2214.1 ± 2264.0	601.3 ± 664.6	269.9 ± 217.3	97.2 ± 21.0	0.0 ± 0.0	3.0 ± 5.0
Uterus	DA	194.0 ± 122.7	1069.7 ± 908.8	426.3 ± 422.7	256.6 ± 340.3	68.4 ± 14.9	1.8 ± 2.1	3.6 ± 3.5
Heart	MON	44.3 ± 18.2	79.0 ± 91.0	21.5 ± 3.6	5.8 ± 5.7	3.7 ± 6.5	0.0 ± 0.0	0.0 ± 0.0
Heart	DA	45.8 ± 19.1	86.1 ± 81.8	42.1 ± 7.7	17.6 ± 4.9	6.3 ± 5.6	0.0 ± 0.0	0.0 ± 0.0
Kidney	MON	146.6 ± 133.3	139.8 ± 98.6	68.3 ± 25.4	48.8 ± 27.5	14.1 ± 10.3	0.0 ± 0.0	8.1 ± 14.0
Kidney	DA	1832.9 ± 2990.7	218.6 ± 114.6	264.8 ± 33.7	244.0 ± 25.8	109.0 ± 22.5	44.6 ± 2.5	0.9 ± 1.4
Marrow	MON	583.1 ± 978.7	257.0 ± 226.1	48.4 ± 60.3	10.7 ± 14.8	0.1 ± 0.2	0.0 ± 0.0	0.0 ± 0.0
Marrow	DA	446.2 ± 744.7	209.9 ± 183.6	66.1 ± 51.3	27.6 ± 29.1	3.8 ± 1.9	0.0 ± 0.0	0.0 ± 0.0
Liver	MON	729.3 ± 993.8	169.0 ± 129.8	66.4 ± 23.4	13.9 ± 4.6	33.0 ± 36.6	0.0 ± 0.0	0.0 ± 0.0
Liver	DA	536.2 ± 725.7	142.0 ± 83.4	87.2 ± 13.9	42.2 ± 12.1	36.3 ± 14.4	3.1 ± 3.0	0.0 ± 0.0
Lung	MON	72.2 ± 53.3	398.3 ± 491.2	50.6 ± 33.7	244.8 ± 407.7	26.7 ± 25.6	47.6 ± 82.5	0.0 ± 0.0
Lung	DA	56.5 ± 29.8	222.3 ± 257.4	72.1 ± 28.2	180.7 ± 267.3	23.8 ± 16.9	30.2 ± 52.3	0.0 ± 0.0
Thymus	MON	22.3 ± 9.2	140.0 ± 144.2	32.6 ± 36.1	1.8 ± 1.1	22.8 ± 6.3	0.0 ± 0.00	0.0 ± 0.0
Thymus	DA	26.50 ± 7.7	136.05 ± 128.2	57.3 ± 45.6	14.1 ± 3.4	30.6 ± 8.6	0.0 ± 0.0	0.0 ± 0.0
Hypothalamus	MON	2209.3 ± 3684.2	504.1 ± 333.9	226.2 ± 264.4	41.1 ± 43.2	72.3 ± 95.2	0.0 ± 0.0	9.7 ± 16.9
Hypothalamus	DA	1754.0 ± 2942.7	287.1 ± 176.9	145.8 ± 144.6	47.2 ± 9.2	67.7 ± 77.7	0.0 ± 0.0	21.0 ± 36.4

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