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Table 3 The concentrations (ng/mL) of MON and DA in various tissues after oral administration of 100 mg/kg MOIG in male rats (mean ± SD, n = 3)

From: Pharmacokinetics and tissue distribution of monotropein and deacetyl asperulosidic acid after oral administration of extracts from Morinda officinalis root in rats

Tissue/organs Component 0.5 h 1 h 2 h 4 h 8 h 12 h 24 h
Small intestine MON 162.8 ± 134.4 19,075.1 ± 16,724.9 3223.4 ± 3453.3 69.2 ± 114.2 24.6 ± 34.1 45.6 ± 78.9 0.1 ± 0.1
DA 132.2 ± 101.9 13,371.3 ± 11,978.3 2053.3 ± 2478.3 495.0 ± 838.1 110.7 ± 152.2 124.9 ± 197.2 4.3 ± 6.2
Large intestine MON 706.8 ± 659.0 924.9 ± 972.6 576.9 ± 380.8 66.1 ± 79.2 58.3 ± 29.9 18.6 ± 4.0 1.7 ± 3.0
DA 2564.7 ± 3177.5 1928.8 ± 1640.6 3135.9 ± 2828.6 1310.0 ± 2008.0 994.9 ± 873.6 334.6 ± 69.8 26.0 ± 23.5
Stomach MON 2888.7 ± 235.2 1052.1 ± 402.1 364.5 ± 141.9 11.7 ± 11.8 91.0 ± 21.5 12.1 ± 20.9 1.0 ± 1.7
DA 2451.1 ± 638.1 1124.3 ± 210.2 435.1 ± 96.7 39.5 ± 21.6 84.1 ± 34.5 20.9 ± 34.5 3.2 ± 5.5
Spleen MON 14.6 ± 9.8 75.2 ± 71.0 5434.0 ± 9376.5 66.6 ± 113.9 4.6 ± 7.9 0.2 ± 0.3 49.8 ± 86.2
DA 14.1 ± 8.7 58.9 ± 49.4 3563.4 ± 6127.5 9.5 ± 1.9 6.6 ± 6.1 3.2 ± 4.6 29.6 ± 51.2
Testis MON 18.4 ± 3.8 16.3 ± 15.3 56.6 ± 11.3 188.4 ± 304.1 304.2 ± 513.5 0.0 ± 0.0 0.0 ± 0.0
DA 17.1 ± 4.9 79.1 ± 67.0 69.1 ± 11.2 24.8 ± 5.6 221.0 ± 358.6 0.0 ± 0.0 0.8 ± 1.3
Heart MON 24.3 ± 10.6 545.5 ± 908.9 8.9 ± 1.9 0.0 ± 0.0 0.2 ± 0.3 0.0 ± 0.0 269.2 ± 466.2
DA 22.7 ± 7.4 533.2 ± 856.8 28.9 ± 0.8 10.0 ± 1.9 2.2 ± 1.9 0.0 ± 0.0 214.3 ± 371.2
Kidney MON 48.6 ± 19.5 147.8 ± 109.9 30.7 ± 4.3 17.0 ± 4.3 3.5 ± 1.7 4.2 ± 7.2 0.0 ± 0.0
DA 91.7 ± 15.9 303.2 ± 162.0 220.2 ± 19.4 202.2 ± 40.2 66.1 ± 6.5 31.5 ± 18.8 2.5 ± 4.4
Marrow MON 82.8 ± 46.8 24.2 ± 23.6 10.1 ± 2.9 5.8 ± 6.6 1.2 ± 2.0 0.0 ± 0.0 0.0 ± 0.0
DA 102.7 ± 90.0 37.8 ± 21.0 24.8 ± 5.1 11.4 ± 3.3 5.6 ± 7.0 0.0 ± 0.0 0.0 ± 0.0
Liver MON 15.6 ± 7.0 26.5 ± 7.9 20.3 ± 5.2 10.3 ± 3.9 12.6 ± 9.3 20.4 ± 35.3 0.0 ± 0.0
DA 17.5 ± 2.4 46.9 ± 15.9 52.0 ± 7.6 35.4 ± 7.7 20.9 ± 5.4 22.9 ± 31.9 0.0 ± 0.0
Lung MON 58.9 ± 29.3 28.7 ± 23.1 34.7 ± 13.9 9.5 ± 6.3 2.0 ± 0.3 64.3 ± 96.8 0.0 ± 0.0
DA 47.5 ± 23.8 47.1 ± 8.6 48.5 ± 10.5 23.9 ± 2.5 6.4 ± 0.7 72.4 ± 116.7 3.9 ± 6.7
Thymus MON 16.8 ± 11.5 11.6 ± 3.8 13.0 ± 2.8 13.0 ± 11.1 6.4 ± 1.3 0.0 ± 0.0 0.0 ± 0.0
DA 22.7 ± 14.6 23.0 ± 3.5 29.7 ± 5.0 10.1 ± 1.9 4.5 ± 3.2 0.8 ± 1.4 1.5 ± 2.0
Hypothalamus MON 152.5 ± 76.3 110.3 ± 58.0 122.7 ± 137.7 27.7 ± 39.7 16.4 ± 14.2 0.0 ± 0.0 0.0 ± 0.0
DA 101.0 ± 19.9 70.9 ± 27.6 74.7 ± 88.3 32.5 ± 29.7 17.1 ± 14.9 4.8 ± 8.3 2.6 ± 4.6