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Table 1 The main pharmacokinetic parameters after oral administration of 25, 50, and 100 mg/kg for MOIG, and 1650 mg/kg for MO or intravenous administration of 25 mg/kg MOIG in male rats (n = 3, mean ± SD)

From: Pharmacokinetics and tissue distribution of monotropein and deacetyl asperulosidic acid after oral administration of extracts from Morinda officinalis root in rats

Parameters Component po-MOIG-25 po-MOIG-50 po-MOIG-100 po-MO-1650 iv-MOIG-25
AUC0-t (μg·h/L) MON 832 ± 322 1505 ± 189 1777 ± 537 875 ± 182 21,501 ± 4877
DA 2010 ± 545 3262 ± 423 3366 ± 753 2220 ± 820 10,239 ± 2044
AUC0-∞ (μg·h/L) MON 872 ± 334 1585 ± 279 1812 ± 550 877 ± 182 21,500 ± 4859
DA 2069 ± 557 3301 ± 411 3397 ± 748 2286 ± 773 10,239 ± 2044
AUMC0-∞ (μg·h/L) MON 5121 ± 2698 8645 ± 5804 5011 ± 2132 3064 ± 882 15,255 ± 5098
DA 14,739 ± 5191 17,844 ± 2090 15,476 ± 3663 12,867 ± 5938 8079 ± 2340
MRT (h) MON 5.71 ± 1.96 5.17 ± 2.58 2.68 ± 0.40 3.47 ± 0.43 0.70 ± 0.09
DA 7.03 ± 0.68 5.41 ± 0.24 4.58 ± 0.15 5.43 ± 0.94 0.78 ± 0.09
t1/2 (h) MON 4.60 ± 1.41 7.11 ± 2.18 2.76 ± 1.84 3.00 ± 0.45 1.85 ± 1.67
DA 4.80 ± 0.62 3.80 ± 1.01 3.76 ± 0.64 3.65 ± 1.16 2.90 ± 0.65
Tmax (h) MON 1.00 ± 0.00 0.92 ± 0.14 0.92 ± 0.52 1.17 ± 0.29 0.03 ± 0.00
DA 2.33 ± 0.76 2.00 ± 0.87 1.5 ± 0.00 2.17 ± 0.76 0.03 ± 0.00
Vd (L/g) MON 0.20 ± 0.04 0.32 ± 0.04 0.22 ± 0.13 8.51 ± 2.61 0.004 ± 0.004
DA 0.09 ± 0.04 0.08 ± 0.03 0.17 ± 0.06 3.90 ± 0.90 0.011 ± 0.004
CL (L/g·h) MON 0.031 ± 0.010 0.032 ± 0.006 0.059 ± 0.020 1.932 ± 0.361 0.001 ± 0.000
DA 0.013 ± 0.004 0.015 ± 0.002 0.030 ± 0.006 0.791 ± 0.310 0.003 ± 0.001
Cmax (μg/L) MON 203 ± 34 451 ± 35 605 ± 114 265 ± 82 39,748 ± 3398
DA 236 ± 54 624 ± 63 664 ± 89 379 ± 91 19,126 ± 1461
F (%) MON 4.06 ± 1.55 3.69 ± 0.65 2.11 ± 0.64 2.04 ± 0.42
DA 20.21 ± 5.44 16.12 ± 2.01 8.29 ± 1.83 11.16 ± 3.77