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Table 4 Changes in the Nutritional Hematological and Inflammation Biomarkers

From: Effects of acupuncture on nutritional state of patients with stable chronic obstructive pulmonary disease (COPD): re-analysis of COPD acupuncture trial, a randomized controlled trial

 

Baseline

After 12 weeks

Change from baseline to post treatment measurements

MD

95% CI

Effect size (d)

Nutritional Hematological

RBP (mg/dL)

 PAG (n 20)

3.0 [0.7]

3.0 [0.6]

0.02 [0.5]

0.98

0.48, 1.46

1.60

 RAG (n 22)

3.3 [1.5]

4.3 [1.3]

1.0 [0.7]

PA (mg/dL)

 PAG (n 32)

23.4 [3.7]

22.9 [4.6]

−0.5 [2.6]

2.84

0.93, 4.76

0.77

 RAG (n 30)

23.0 [4.9]

25.4 [6.7]

2.4 [4.7]

Tf (mg/dL)

 PAG (n 20)

218.9 [76.6]

208.0 [67.9]

−10.9 [8.8]

54.1

34.53, 71.82

2.94

 RAG (n 22)

216.4 [38.1]

259.6 [45.0]

43.2 [24.0]

Hb (g/dL)

 PAG (n 32)

14.1 [1.1]

13.9 [1.2]

−0.2 [0.9]

0.90

0.54, 1.27

1.17

 RAG (n 30)

13.9 [1.6]

14.6 [1.3]

0.7 [0.6]

Inflammation Biomarkers

Hs-CRP (ng/mL)

 PAG (n 12)

735.3 [445.6]

717.8 [396.6]

−17.4 [71.7]

− 576.58

− 610.60, −44.23

1.57

 RAG (n 10)

1109.3 [437.2]

515.3 [247.6]

− 594.0 [542.4]

TNF-α (pg/mL)

 PAG (n 12)

2.5 [0.9]

2.8 [1.0]

0.4 [0.8]

−2.09

−2.44, −0.42

1.56

 RAG (n 10)

3.3 [1.5]

1.6 [1.2]

−1.7 [1.8]

IL-6 (pg/mL)

 PAG (n 12)

2.9 [1.0]

3.6 [1.4]

0.7 [1.5]

−2.34

−3.13, −0.87

1.55

 RAG (n 10)

3.3 [1.1]

1.7 [1.0]

−1.7 [1.6]

SAA (μg/mL)

 PAG (n 12)

5.0 [1.7]

5.5 [2.4]

0.5 [1.0]

−2.10

−3.34, −1.02

1.75

 RAG (n 10)

4.4 [1.7]

2.7 [0.8]

−1.6 [1.4]

COHb (%)

 PAG (n 32)

1.4 [1.0]

1.9 [1.1]

0.5 [0.9]

−1.13

−1.51, −0.69

1.10

 RAG (n 30)

1.4 [1.2]

0.8 [0.6]

−0.6 [1.1]

  1. MD mean difference, RBP Retinol-Binding Protein, PA Pre-Albumin, Tf Transferrin, Hb Hemoglobin, Hs-CRP High sensitivity C-reactive protein, TNF-α Tumor Necrosis Factor-alpha, IL-6 Interleukin 6, SAA Serum Amyloid A, COHb carboxyhemoglobin