The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system

Table 2 Effect of MECN on open field test

Treatment	Dose (mg/kg)	Number of square crossed (% of Inhibition)
Treatment	Dose (mg/kg)	Pretreatment	30 min	60 min	90 min	120 min
Control	0.1 ml/mouse	103.80 ± 3.51	94.40 ± 4.31	83.20 ± 3.09	74.60 ± 3.20	66.80 ± 2.58
Diazepam	1	101.60 ± 3.89	49.20 ± 2.13*** (47.88)	33.20 ± 1.88*** (60.10)	14.80 ± 1.28*** (80.16)	5.40 ± 1.12*** (91.92)
MECN	50	98.00 ± 2.83	67.40 ± 3.79*** (28.60)	42.00 ± 2.49*** (49.52)	31.60 ± 2.87*** (57.64)	16.20 ± 2.40*** (75.75)
MECN	100	100.80 ± 2.62	46.40 ± 2.75*** (50.85)	35.80 ± 2.48*** (56.97)	16.20 ± 4.53*** (78.28)	5.60 ± 0.75*** (91.62)
MECN	200	102.20 ± 3.44	34.40 ± 3.23*** (63.56)	22.20 ± 3.88*** (73.32)	10.80 ± 2.89*** (85.52)	4.20 ± 0.58*** (93.71)

Effect of MECN on open field test. Values are presented as the Mean ± SEM (n = 5). MECN = Methanolic extract of Crataeva nurvala; ***p < 0.001 compared with the control group (two-way ANOVA followed by Bonferroni’s test)

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