Fig. 4

Apoptosis triggered by treatment with Asteraceae plant extracts on MIA Paca-2 cells. Activation of caspase 3 and 7 after 48 h treatment with Yarrow SFE extracts (a) or with Marigold SFE extracts (b), with the positive (Staurosporine 1,5 μM) and negative (Marjoram SFE 100 μg/mL) controls. Data represent means ± S.E.M of three independent experiments each performed in duplicate. Asterisks indicate statistical differences in treated cells with respect to the control (non-treated cells, DMSO 0.1%). **p < 0.01; ***p < 0.001