Efficacy of Sida pilosa Retz aqueous extract against Schistosoma mansoni – induced granulomatous inflammation in the liver and the intestine of mice: histomorphometry and gastrointestinal motility evaluation

Table 2 Effect of oral treatment of Sida pilosa aqueous extract on plasma total proteins and transaminases activities of Schistosoma mansoni-infected mice

Groups	Total proteins		ALT		AST
Groups	Concentration (mg/mL)	% change	Activity (UI/L)	% change	Activity (UI/L)	% change
UIC	0.91 ± 0.03		116.33 ± 14.28		113.59 ± 9.29
IC	0.79 ± 0.02^*	- 13.19	842.60 ± 91.12^***	+ 624.32	267.81 ± 16.34^***	+ 135.77
PZQ	0.77 ± 0.03^*	/	171.64 ± 15.69^###	- 79.63	179.78 ± 10.58^{**, ###}	- 32.87
SpAE 200	0.90 ± 0.03^{#, £}	+ 13.92	159.29 ± 16.13^###	- 81.09	136.76 ± 9.78^{###, £}	- 48.93

UIC Uninfected-untreated mice, IC Infected-untreated mice, PZQ Infected mice treated with praziquantel, SpAE 200 Infected mice treated with Sida pilosa aqueous extract at 200 mg/kg
Data are expressed as mean ± SEM (n = 6). ANOVA followed by Newman-Keuls multiple comparison test was used for statistical analysis. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001: values are significantly different from those of uninfected-untreated mice (group UIC). ^#p < 0.05, ^###p < 0.001: values are significantly different from those of infected-untreated mice (group IC). ^£p < 0.05: values are significantly different from those of infected mice treated with praziquantel (group PZQ)

ISSN: 2662-7671