Table 2 Serum biochemistry data of male and female F344 rats orally administered with Tiglium seed extract for 13Â weeks
From: Assessment of acute, 14-day, and 13-week repeated oral dose toxicity of Tiglium seed extract in rats
| Â | Dose of Tiglium seed (mg/kg) | |||||
|---|---|---|---|---|---|---|
0a | 31.25 | 62.5 | 125 | 250 | 500 | |
Males | ||||||
 BUN (mg/dL) | 22 ± 3.0 | 23 ± 3.7 | 24 ± 4.6 | 23 ± 3.8 | 22 ± 4.2 | 22 ± 4.0 |
 TC (mg/dL) | 71 ± 7.2 | 74 ± 5.7 | 73 ± 7.3 | 77 ± 5.8 | 69 ± 6.2 | 69 ± 6.8 |
 TP (g/dL) | 6.8 ± 0.18 | 7.0 ± 0.19 | 7.1 ± 0.19* | 7.2 ± 0.25* | 6.8 ± 0.20 | 6.8 ± 0.13 |
 Albumin (g/dL) | 3.0 ± 0.05 | 3.1 ± 0.09 | 3.2 ± 0.10* | 3.2 ± 0.16 | 3.1 ± 0.10 | 3.1 ± 0.08 |
 TB (mg/dL) | 0.1 ± 0.00 | 0.1 ± 0.00 | 0.1 ± 0.00 | 0.1 ± 0.00 | 0.1 ± 0.00 | 0.1 ± 0.00 |
 ALP (IU/L) | 207 ± 22.8 | 219 ± 43.4 | 210 ± 26.1 | 201 ± 33.2 | 188 ± 22.3 | 189 ± 27.3 |
 AST (IU/L) | 172 ± 51.0 | 150 ± 29.5 | 161 ± 32.6 | 161 ± 31.8 | 132 ± 34.1 | 125 ± 27.2* |
 ALT (IU/L) | 83 ± 22.4 | 70 ± 10.5 | 75 ± 12.2 | 81 ± 11.5 | 74 ± 11.8 | 67 ± 7.8 |
 Creatinine (mg/dL) | 0.6 ± 0.05 | 0.5 ± 0.05 | 0.6 ± 0.07 | 0.6 ± 0.07 | 0.5 ± 0.05 | 0.6 ± 0.05 |
 TG (mg/dL) | 194 ± 39.2 | 210 ± 35.8 | 178 ± 38.3 | 221 ± 82.7 | 180 ± 55.4 | 151 ± 40.7 |
Females | ||||||
 BUN (mg/dL) | 22 ± 5.5 | 21 ± 4.7 | 20 ± 3.9 | 19 ± 3.4 | 20 ± 4.4 | 18 ± 3.0 |
 TC (mg/dL) | 95 ± 7.4 | 93 ± 10.6 | 93 ± 8.5 | 85 ± 8.9* | 84 ± 7.2* | 81 ± 7.1* |
 TP (g/dL) | 6.5 ± 0.32 | 6.6 ± 0.22 | 6.6 ± 0.15 | 6.2 ± 0.29* | 6.3 ± 0.20 | 6.4 ± 0.21 |
 Albumin (g/dL) | 3.0 ± 0.15 | 3.0 ± 0.11 | 3.0 ± 0.08 | 2.8 ± 0.12* | 2.9 ± 0.09 | 2.9 ± 0.12 |
 TB (mg/dL) | 0.1 ± 0.00 | 0.1 ± 0.00 | 0.1 ± 0.00 | 0.1 ± 0.00 | 0.1 ± 0.00 | 0.1 ± 0.00 |
 ALP (IU/L) | 176 ± 21.1 | 187 ± 19.9 | 199 ± 39.0 | 184 ± 32.7 | 182 ± 30.5 | 166 ± 27.9 |
 AST (IU/L) | 148 ± 35.1 | 152 ± 30.9 | 150 ± 29.4 | 134 ± 26.9 | 143 ± 33.8 | 137 ± 32.2 |
 ALT (IU/L) | 71 ± 17.3 | 70 ± 13.8 | 66 ± 6.9 | 63 ± 10.0 | 63 ± 9.1 | 55 ± 7.0* |
 Creatinine (mg/dL) | 0.6 ± 0.10 | 0.6 ± 0.07 | 0.6 ± 0.05 | 0.6 ± 0.07 | 0.7 ± 0.07 | 0.6 ± 0.04 |
 TG (mg/dL) | 81 ± 28.4 | 66 ± 11.5 | 78 ± 22.0 | 59 ± 15.6* | 60 ± 10.4* | 63 ± 16.7 |