Table 4 Adverse events of CAM for childhood atopic eczema in randomized controlled trials

C. Gore 2011 [43]

T: 42/137

C: NR

green loose stools;

increased vomiting;

feed-refusal;

colic

NR

24/137 (17.5%) participants stopped the study formula.

Chen YL 2015 [24]

T: 1/58

C: 2/58

1 for dizzy.

1 for dizzy;

1 for drowsy.

NR

Liu CH 2009 [20]

T: 0/150

C: 57/148

None

21 for facial flushing;

18 for dry skin;

8 for partial facial skin thinning;

10 for facial skin with mild pigmentation;

Unclear for other hormonal dermatitis symptoms.

NR

Sergei V. Gerasimov 2010 [37]

T: 26/48

C: 24/48

11 for upper respiratory tract infections;

4 for lower respiratory tract infections;

7 for herpetic stomatitis;

3 for diarrhea;

6 for constipation;

5 for abdominal colic;

2 for burn and croup with severe adverse events.

10 for upper respiratory tract infections;

5 for lower respiratory tract infections;

5 for herpetic stomatitis;

2 for diarrhea;

6 for constipation;

4 for abdominal colic;

3for head injury, food poisoning with severe adverse events.

None was related to the medications under

investigation.

Wu YQ 2014 [22]

T: 2/74

C: 5/74

2 for crying and mildly red skin lesions on the 2nd day.

5 for crying, irritability, and red skin lesions.

Without any treatment, to ease soon and symptoms disappearance.

Ye CQ

2017 [30]

T:3/48

C:14/48

1 for diarrhea;

2 for constipation.

6 for diarrhea;

8 for constipation.

NR

Zhang XN 2013 [32]

T: 1/36

C: 2/34

1 for mild skin irritation after using Velvetfeeling Lotion

2 forskin lesions reddening after using Butyl Flufenamate Ointment.

Without any treatment, to ease soon and symptoms disappearance.