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Table 4 Cytotoxic effects of the tested fractions

From: Isolation of anticancer constituents from Cucumis prophetarum var. prophetarum through bioassay-guided fractionation

 

IC50 a (μg/mL)

Fractions

MCF-7

MDA MB 231

A2780

A2780 CP

HepG2

HCT-116

Hexane fraction

19.7

0.76

7.15

20.27

55.4

25

Ethyl acetate fraction

17.5

0.35

2.82

19.2

28.5

14.2

n-Butanol fraction

218.4

43

94.01

273

358.5

169.5

Water fraction

> 1000

> 1000

> 1000

> 1000

> 1000

> 1000

Fraction I

3.5

0.15

4.9

5.9

0.27

0.15

Fraction III

6.80

0.12

20.5

17.5

0.52

0.65

  1. Inhibitory effects of the fractions from the extract of Cucumis prophetarum var. prophetarum fruits on the proliferation of MCF7, MDA-MB-231, HCT-116, A2780, A2780CP, and HepG2. Cell were treated with 0–1000 μg/ml. a IC50: is the concentration that inhibited cell proliferation by 50%. n = 8
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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