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Table 3 Effects of TAU-CL, AZA, and their combination on the percentage of DNA fragmentation, Caspase 9 activity, and Bcl-2 expression in different groups

From: Ameliorative effect of taurine-chloramine in azathioprine-induced testicular damage; a deeper insight into the mechanism of protection

Groups

Group I

(Control)

Group II

(TAU-CL)

Group III

(AZA)

Group IV

(TAU-CL/AZA)

Parameters

DNA fragmentation (%)

68.2 ± 5.01

70.55± 6

91.59a ± 10.59

68.19b ± 4.8

Caspase-9 activity

(ng/g tissue)

1.6 ± 0.15

1.7 ± 0.07

2.5a ± 0.13

1.6b ± 0.17

BCL2

(ng/mg tissue)

1.25 ± 0.02

1.3 ± 0.08

0.75a ± 0.05

1.2b ± 0.13

  1. The percentage of DNA fragmentation, Caspase 9 activity, and Bcl-2 expression, measured by western blot, β-actin was used as a loading control (C), in different groups
  2. Data are expressed as the mean ± SEM, and data were analyzed using one-way ANOVA followed by the Bonferroni post hoc multiple comparison test (n = 10). Difference between groups were considered statistically significant at P ≤ 0.05. (a) Significant values versus the group control, (b) Significant values versus the AZA group
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