Reducing antibiotic use for uncomplicated urinary tract infection in general practice by treatment with uva-ursi (REGATTA) – a double-blind, randomized, controlled comparative effectiveness trial

Table 1 Participant timeline in REGATTA

Activity	Baseline	Follow-up
Day	0	1	2	3	4	5	6	7	28
Visit Number	I								II
Screening	X
Informed Consent	X
Inclusion / Exclusion criteria	X
Medical History, Examination	X
Urine Tests^a	X
Pregnancy Test	X
Drug Intake^b	X	X	X	X	X	X
Symptom Assessment and Activity Impairment (Diary)	X	X	X	X	X	X	X	X
Additional Antibiotic Courses		X	X	X	X	X	X	X	X
Painkiller Intake		X	X	X	X	X	X	X	X
Adverse Events and Complications		X	X	X	X	X	X	X	X
Recurrent UTI (Questionnaire)									X
Return of Drug Packages									X
Phone Calls to Remind Patients (Diary, Drug Return, Questionnaire)		X						X	X

^aMidstream urine for on-site dipstick test (leukocytes, nitrite, red blood cells) and for urine culture (pathogens and resistances)
^bDrug intake until all 30 tablets are finished (= 3 × 2 tablets uva-ursi daily for 5 days)

ISSN: 2662-7671