Variable | Week 0 | Week 6 | Week 12 | Overall P Value | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Placeboa | Low TT | High TT | Placebo | Low TT | High TT | Placebo | Low TT | High TT | Â | |
AST (U/L) | 23.01 (10.68) | 20.76 (6.57) | 20.77 (4.95) | 21.46 (5.53) | 20.76 (6.76) | 22.07 (7.97) | 21 (5.23) | 20.21 (9.39) | 21.9 (7.63) | 0.515 |
ALT (U/L) | 23.75 (11.49) | 19.9 (8.35) | 19.03 (7.83) | 20.82 (8.77) | 19.66 (8.88) | 20.5 (10.34) | 21.14 (8.67) | 18.72 (8.65) | 19.57 (10.76) | 0.494 |
Bilirubin (mg/dL) | 0.53 (0.19) | 0.52 (0.14) | 0.57 (0.15) | 0.46 (0.21) | 0.48 (0.13) | 0.43 (0.11) | 0.5 (0.19) | 0.47 (0.15) | 0.47 (0.12) | 0.583 |
ALP (U/L) | 72.75 (14.68) | 79.59 (15.53) | 79.23 (22.96) | 74.04 (16.95) | 76.28 (18.04) | 75.23 (16.56) | 74.64 (15.6) | 75.14 (16.31) | 74.4 (16.99) | 0.730 |
BUN (mg/dL) | 14.46 (3.48) | 16.41 (4.6) | 16.57 (4.26) | 14.86 (3.33) | 15.62 (3.53) | 17.07 (4.18) | 15.54 (3.96) | 16.97 (3.74) | 16.67 (4.44) | 0.120 |
Creatinine (mg/dL) | 0.79 (0.12) | 0.85 (0.13) | 0.83 (0.12) | 0.82 (0.12) | 0.87 (0.15) | 0.86 (0.15) | 0.82 (0.13) | 0.89 (0.17) | 0.83 (0.12) | 0.111 |
Ca (mg/dL) | 9.62 (0.38) | 9.54 (0.37) | 9.48 (0.29) | 9.44 (0.35) | 9.41 (0.36) | 9.37 (0.39) | 9.57 (0.34) | 9.55 (0.53) | 9.5 (0.28) | 0.607 |
Na (mmol/L) | 138.86 (3.43) | 139.72 (1.56) | 139.27 (2.33) | 139.5 (2.85) | 140.03 (2.5) | 140.1 (2.17) | 139.75 (1.9) | 140.48 (2.35) | 140.37 (2.51) | 0.346 |
K (mmol/L) | 3.99 (0.28) | 4.03 (0.36) | 4.02 (0.35) | 3.83 (0.24) | 3.77 (0.29) | 3.78 (0.4) | 3.84 (0.32) | 3.91 (0.31) | 3.79 (0.39) | 0.986 |
Cl (mmol/L) | 103.71 (3.55) | 104.1 (2.55) | 104.1 (2.92) | 103.61 (2.81) | 103.55 (2.32) | 104.5 (1.87) | 103.29 (2.68) | 103.9 (3.02) | 104.13 (3.04) | 0.314 |
CO2 (mmol/L) | 21.68 (2.28) | 22.48 (2.29) | 22.87 (2.61) | 19.79 (2.22) | 21.1 (1.97) | 20.83 (2.35) | 20.89 (1.83) | 21.45 (1.74) | 20.67 (2.92) | 0.086 |
Glucose (mg/dL) | 90.61 (10.78) | 88.21 (13.91) | 85.8 (15.05) | 87.43 (11.81) | 83.34 (12.29) | 83.27 (14.1) | 84.75 (11.78) | 83.83 (12.74) | 83.83 (11.75) | 0.282 |
Protein, total (g/dL) | 7.19 (0.41) | 7.23 (0.48) | 7.17 (0.54) | 7.2 (0.37) | 7.24 (0.4) | 7.2 (0.45) | 7.29 (0.33) | 7.24 (0.44) | 7.31 (0.41) | 0.810 |
Albumin (g/dL) | 4.39 (0.26) | 4.36 (0.21) | 4.35 (0.26) | 4.32 (0.24) | 4.28 (0.2) | 4.26 (0.18) | 4.41 (0.19) | 4.33 (0.21) | 4.38 (0.19) | 0.474 |
Globulin (g/dL) | 2.8 (0.35) | 2.87 (0.41) | 2.82 (0.45) | 2.89 (0.3) | 2.97 (0.41) | 2.95 (0.39) | 2.87 (0.28) | 2.91 (0.37) | 2.94 (0.38) | 0.468 |
Albumin/globulin | 1.59 (0.22) | 1.55 (0.25) | 1.59 (0.26) | 1.52 (0.19) | 1.48 (0.23) | 1.46 (0.21) | 1.55 (0.16) | 1.52 (0.2) | 1.52 (0.22) | 0.451 |