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Table 3 Effect of tocotrienol supplementation on blood parameters in postmenopausal osteopenic women

From: A 12-week evaluation of annatto tocotrienol supplementation for postmenopausal women: safety, quality of life, body composition, physical activity, and nutrient intake

Variable Week 0 Week 6 Week 12 Overall P Value
Placeboa Low TT High TT Placebo Low TT High TT Placebo Low TT High TT  
AST (U/L) 23.01 (10.68) 20.76 (6.57) 20.77 (4.95) 21.46 (5.53) 20.76 (6.76) 22.07 (7.97) 21 (5.23) 20.21 (9.39) 21.9 (7.63) 0.515
ALT (U/L) 23.75 (11.49) 19.9 (8.35) 19.03 (7.83) 20.82 (8.77) 19.66 (8.88) 20.5 (10.34) 21.14 (8.67) 18.72 (8.65) 19.57 (10.76) 0.494
Bilirubin (mg/dL) 0.53 (0.19) 0.52 (0.14) 0.57 (0.15) 0.46 (0.21) 0.48 (0.13) 0.43 (0.11) 0.5 (0.19) 0.47 (0.15) 0.47 (0.12) 0.583
ALP (U/L) 72.75 (14.68) 79.59 (15.53) 79.23 (22.96) 74.04 (16.95) 76.28 (18.04) 75.23 (16.56) 74.64 (15.6) 75.14 (16.31) 74.4 (16.99) 0.730
BUN (mg/dL) 14.46 (3.48) 16.41 (4.6) 16.57 (4.26) 14.86 (3.33) 15.62 (3.53) 17.07 (4.18) 15.54 (3.96) 16.97 (3.74) 16.67 (4.44) 0.120
Creatinine (mg/dL) 0.79 (0.12) 0.85 (0.13) 0.83 (0.12) 0.82 (0.12) 0.87 (0.15) 0.86 (0.15) 0.82 (0.13) 0.89 (0.17) 0.83 (0.12) 0.111
Ca (mg/dL) 9.62 (0.38) 9.54 (0.37) 9.48 (0.29) 9.44 (0.35) 9.41 (0.36) 9.37 (0.39) 9.57 (0.34) 9.55 (0.53) 9.5 (0.28) 0.607
Na (mmol/L) 138.86 (3.43) 139.72 (1.56) 139.27 (2.33) 139.5 (2.85) 140.03 (2.5) 140.1 (2.17) 139.75 (1.9) 140.48 (2.35) 140.37 (2.51) 0.346
K (mmol/L) 3.99 (0.28) 4.03 (0.36) 4.02 (0.35) 3.83 (0.24) 3.77 (0.29) 3.78 (0.4) 3.84 (0.32) 3.91 (0.31) 3.79 (0.39) 0.986
Cl (mmol/L) 103.71 (3.55) 104.1 (2.55) 104.1 (2.92) 103.61 (2.81) 103.55 (2.32) 104.5 (1.87) 103.29 (2.68) 103.9 (3.02) 104.13 (3.04) 0.314
CO2 (mmol/L) 21.68 (2.28) 22.48 (2.29) 22.87 (2.61) 19.79 (2.22) 21.1 (1.97) 20.83 (2.35) 20.89 (1.83) 21.45 (1.74) 20.67 (2.92) 0.086
Glucose (mg/dL) 90.61 (10.78) 88.21 (13.91) 85.8 (15.05) 87.43 (11.81) 83.34 (12.29) 83.27 (14.1) 84.75 (11.78) 83.83 (12.74) 83.83 (11.75) 0.282
Protein, total (g/dL) 7.19 (0.41) 7.23 (0.48) 7.17 (0.54) 7.2 (0.37) 7.24 (0.4) 7.2 (0.45) 7.29 (0.33) 7.24 (0.44) 7.31 (0.41) 0.810
Albumin (g/dL) 4.39 (0.26) 4.36 (0.21) 4.35 (0.26) 4.32 (0.24) 4.28 (0.2) 4.26 (0.18) 4.41 (0.19) 4.33 (0.21) 4.38 (0.19) 0.474
Globulin (g/dL) 2.8 (0.35) 2.87 (0.41) 2.82 (0.45) 2.89 (0.3) 2.97 (0.41) 2.95 (0.39) 2.87 (0.28) 2.91 (0.37) 2.94 (0.38) 0.468
Albumin/globulin 1.59 (0.22) 1.55 (0.25) 1.59 (0.26) 1.52 (0.19) 1.48 (0.23) 1.46 (0.21) 1.55 (0.16) 1.52 (0.2) 1.52 (0.22) 0.451
  1. aValues are mean(SD). AST asparate aminotransferase, ALT alanine aminotransferase, ALP alkaline phosphatase, BUN blood urea nitrogen, Ca calcium, Cl chloride, CO2 carbon dioxide, K potassium, Na sodium