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Table 7 Effects of P. racemosa leaves AME and silymarin on ALT and AST in paracetamol induced hepatotoxicity in rats

From: Phenolic profile, anti-inflammatory, antinociceptive, anti-ulcerogenic and hepatoprotective activities of Pimenta racemosa leaves

Item (IU/L)

Group (dose in mg/kg b.wt.)

Negative Control

Paracetamol640

Silymarin 25

% of change

80% AME of P. racemosa leaves

125

% of change

250

% of change

500

% of change

ALT

15.61 ± 0.65*

46.42 ± 1.8

20.02 ± 1.8*

56.87

25.83 ± 2.4*@

44.36

20.71 ± 1.58*

55.39

18.89 ± 1.17*

59.3

AST

94.77 ± 7.6*

152.6 ± 7.2

114.2 ± .2.0*

25.16

117.9 ± 2.0*.

22.74

111.1 ± 4.28*

27.19

138.6 ± 4.7

9.2

  1. Values represent the mean ± S.E. Data is represented as means ± S.E; n = 8; Data were analyzed using one way analysis of variance (ANOVA) followed by Tukey Kramer multiple comparisons test. Significant at P ≤ 0.05
  2. *Significant difference from positive control paracetamol group; @ Significant difference from negative control group; Percent of change was calculated as regard to paracetamol control group
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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