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Table 6 Effect of P. racemosa leaves AME and ranitidine on gastric mucosal injury induced by ethanol in rats

From: Phenolic profile, anti-inflammatory, antinociceptive, anti-ulcerogenic and hepatoprotective activities of Pimenta racemosa leaves

Treated groups

Dose mg/kg b.wt.

Number of lesions/rat

% change

Severity of lesions/rat

% change

Ethanol (70%)

1 mL

16.20 ± 0.37

–

56.8 ± 0.97

–

Ranitidine

50

2.0 ± 0.31*

87.7

3.2 ± 0.37*

94.4

AME

125

8.6 ± 0.24*@

46.9

26.8 ± 0.37*@

52.8

250

3.4 ± 0.24*@#

79

10 ± 0.44*@#

82.4

500

2.8 ± 0.37*#

82.7

4.8 ± 0.37*#

91.5

  1. Data is represented as means ± S.E; n = 5; Data were analyzed using one way analysis of variance (ANOVA) followed by Tukey Kramer multiple comparisons test; Significant at P ≤ 0.05
  2. *Significant difference from positive control ethanol group; @ Significant different from ranitidine group; # Significant difference from the extract (125 mg/kg) group