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Table 2 Lan-Qin effect on the outcome of HFMD cases $

From: Hand-foot-mouth disease and use of steroids, intravenous immunoglobulin, and traditional Chinese herbs in a tertiary hospital in Shantou, China

  Total Recovery& Death Self-discharge Length of hospital stay (day)
All cases Without self-discharged cases
Mild cases 1900 1807 0 93 4.09 ± 1.8 4.09 ± 1.7
 No Lan-Qin/Other therapies# 368 (19.4) 348 (19.3) 0 (0) 20 (21.5) 4.03 ± 1.6 4.07 ± 1.5
 Lan-Qin only 840 (44.2) 811 (44.9) * 0 (0) 29 (31.2) 3.83 ± 1.5 * 3.89 ± 1.4 *
 Lan-Qin + Other therapies 692 (36.4) 648 (35.9) 0 (0) 44 (47.3) 4.43 ± 2.1 4.40 ± 2.0 **
Severe cases 1196 1061 2 133 5.40 ± 3.0 5.47 ± 2.9
 No Lan-Qin/Other therapies 47 (3.9) 41 (3.9) 0 (0) 6 (4.5) 4.32 ± 2.1 4.39 ± 2.2
 Lan-Qin only 106 (8.9) 97 (9.1) 0 (0) 9 (6.8) 4.25 ± 2.0 4.32 ± 2.0
 Lan-Qin + Other therapies 1043 (87.2) 923 (87.0) 2 (100) 118 (88.7) 5.57 ± 3.1 ** 5.64 ± 3.0 **
Very severe cases 1 0 1 0 16 16
 No Lan-Qin/Other therapies 0 (0) 0 (0) 0 (0) 0 (0)
 Lan-Qin only 0 (0) 0 (0) 0 (0) 0 (0)
 Lan-Qin + Other therapies 1 (100) 0 (0) 1 (100) 0 (0) 16 16
Total 3097 2868 3 226 4.60 ± 2.4 4.60 ± 2.3
 No Lan-Qin/Other therapies 415 (13.4) 389 (13.6) 0 (0) 26 (11.5) 4.07 ± 1.6 4.11 ± 1.6
 Lan-Qin only 946 (30.5) 908 (31.7) 0 (0) 38 (16.8) 3.88 ± 1.6 * 3.89 ± 1.5
 Lan-Qin + Other therapies 1736 (56.1) 1571 (54.8) 3 (100) 162 (71.7) 5.12 ± 2.8 ** 5.14 ± 2.7 **
  1. $Self-discharged cases (n = 302), and the cases treated with steroid only, IVIG only, and steroid/IVIG (n = 602) were excluded from the analysis. &Recovery is defined as clearance of fever, erythema, and CNS and cardiopulmonary complications. #Lan-Qin was the predominant drug among 8 TCHs prescribed; other therapies include steroids, IVIG, or combination of steroids and IVIG
  2. Data are shown as n (%), or mean ± SD for length of hospital stay. *P < 0.05, **P < 0.01, vs. No Lan-Qin/Other therapies (by χ2 test for recovery and t-test for length of hospital stay)