Fig. 3
Electroretinogram (ERG) analysis. a and b Compared to the control retina (Sham), there was a drastic decrease in the ERG b-wave amplitudes after HIOP-induced retinal I/R and pre-administration (a) or post-administration (b) of vehicle. This decrease was dose-dependently counteracted by pre-ischemia administration of DNL (DNL1.0 + I/R; DNL0.5 + I/R; a) or post-ischemia administration of DNL (I/R + DNL1.0; b). c Compared to the normal control (Sham), a significant (**; P < 0.01) decrease in the ERG b-wave ratio occurred in the “Vehicle+I/R” group after retinal I/R. A significant (††; P < 0.01) counteraction of this ischemia-induced reduction was dose-responsive and obtained when there was pre-administration of a high dose (DNL1.0 + I/R) and low dose (DNL0.5 + I/R) of DNL. d ERG b-wave amplitude was found to be significantly (**; P < 0.01) reduced on day 1, 3, 5 or 7 after retinal I/R and post-ischemia administration of vehicle. A significant (†/††; P < 0.05/0.01) alleviation of this reduction in ERG b-wave amplitude was achieved by post-administration of DNL (I/R + DNL1.0). Please refer to definitions of various groups in Table 2. Abbreviations: HIOP, high intraocular pressure; I/R, ischemia plus reperfusion. DNL, Dendrobium nobile Lindley. The results are present as means±S.E.M. (n = 10~ 12)