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Table 2 Levels of cytokines/chemokines in culture medium of pAECs stimulated with LPS (10 μg/ml) in the presence or absence of Cucumis sativus L. extract (CSE 2 mg/ml). Data shown are representative of at least three independent experiments and represent the mean ± SEM. Significant differences are indicated by (p < 0.05) *, and (p < 0.001) by ** nd not detectable

From: Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells

ng/ml 1 h 7 h 24 h
CSE-/LPS+ CSE+/LPS+ CSE-/LPS+ CSE+/LPS+ CSE-/LPS+ CSE+/LPS+
IL-1α nd nd nd nd 0.0592 ± 0.0019 0.0140 ± 00002**
IL-6 nd 0.1574 ± 0.0064 4.3163 ± 0.0893 3.3889 ± 0.0835* 8.0129 ± 0.3067 3.9270 ± 0.0335**
IL-8 6.3445 ± 0.4821 2.3809 ± 0.0434** > 50 24.2300 ± 2.2100 31.5600 ± 3.8210* 25.1500 ± 2.7210
IL-10 0.0077 ± 0.0023 0.0355 ± 0.0010** 0.0187 ± 0.0025 0.0395 ± 0.0034* 0.0209 ± 00017 0.0400 ± 0.0056**
IL-18 0.0319 ± 0.0021 0.1796 ± 0.0049** 0.0572 ± 0.0011 0.1897 ± 0.0033** 0.0606 ± 0.0034 0.1913 ± 0.0056**
GM-CSF 0.1083 ± 0.0071 nd 0.1895 ± 0.0221 nd 0.2061 ± 0.0094 0.0021 ± 0.0037**
IFN-γ 0.0501 ± 0.0436 1.5529 ± 0.0292** 0.2654 ± 0.0889 0.5230 ± 0.0725* 0.0725 ± 0.0378 0.3522 ± 0.0340**