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Table 2 Antimicrobial activity (in μg/ml) of extracts and isolated compounds from D. senegambiensis and A. monticola against bacterial and yeast strains

From: Antimicrobial and antioxidant activities of triterpenoid and phenolic derivatives from two Cameroonian Melastomataceae plants: Dissotis senegambiensis and Amphiblemma monticola

Crude extracts/compounds

Inhibition parameters

S. aureus ATCC25923

S. aureus MSSA1

S. aureus MRSA3

S. aureus MRSA4

C. albicans ATCC10231

C. tropicalis PK233

C. neoformans H99

DSEtOH

MIC

128

64

256

128

2048

1024

512

MMC

256

128

512

256

2048

2048

1024

MMC/MIC

2

2

2

2

1

2

2

DSEtOAc

MIC

256

128

256

256

2048

1024

512

MMC

256

256

512

512

> 2048

> 2048

> 2048

MMC/MIC

1

2

2

1

nd

nd

nd

DSBuOH

MIC

256

64

256

128

2048

1024

1024

MMC

512

128

512

256

2048

> 2048

> 2048

MMC/MIC

2

2

2

2

1

nd

nd

AMEtOH

MIC

256

128

256

256

256

128

256

MMC

256

128

512

512

512

256

256

MMC/MIC

1

1

2

2

2

2

1

AMEtOAc

MIC

512

256

512

512

512

2048

2048

MMC

512

512

512

512

1024

> 2048

> 2048

MMC/MIC

1

2

1

1

2

nd

nd

3

MIC

256

128

128

128

256

256

128

MMC

> 256

> 256

> 256

> 256

> 256

> 256

> 256

MMC/MIC

nd

nd

Nd

nd

nd

nd

nd

4

MIC

> 256

> 256

> 256

> 256

256

256

128

MMC

> 256

> 256

> 256

> 256

> 256

> 256

> 256

MMC/MIC

nd

nd

Nd

nd

nd

nd

nd

5

MIC

64

64

64

128

128

64

128

MMC

128

128

128

256

256

128

128

MMC/MIC

2

2

2

2

2

2

1

6

MIC

32

64

64

128

64

64

64

MMC

64

64

128

128

64

64

128

MMC/MIC

2

1

2

1

1

1

2

7

MIC

32

16

16

32

32

32

32

MMC

32

16

32

64

64

64

32

MMC/MIC

1

1

2

2

2

2

1

8

MIC

32

32

64

128

128

16

32

MMC

64

32

128

256

> 256

16

32

MMC/MIC

2

1

2

2

nd

1

1

9

MIC

256

256

> 256

> 256

> 256

256

256

MMC

> 256

> 256

> 256

> 256

nd

> 256

> 256

MMC/MIC

nd

nd

Nd

nd

nd

nd

nd

10

MIC

8

16

32

32

16

8

16

MMC

16

16

64

32

16

8

16

MMC/MIC

2

1

2

1

1

1

1

10 + 12

MIC

32

16

32

32

64

64

64

MMC

64

64

64

64

128

128

64

MMC/MIC

2

4

2

2

2

2

1

3 + 13

MIC

128

64

> 256

128

> 256

> 256

128

MMC

256

128

Nd

256

> 256

> 256

256

MMC/MIC

2

2

nd

2

nd

nd

2

Reference drugs*

MIC

1

1

16

32

2

0.5

1

MMC

1

1

16

32

2

1

1

MMC/MIC

1

1

1

1

1

2

1

  1. *: Ciprofloxacin for bacteria and nystatin for fungi; compounds 1–6 and compounds 3, 4, 7–14 were isolated from D. senegambiensis and A. monticola respectively; compounds 1–2, 11 and 14 were not tested; nd: not determined. MIC: Minimum Inhibitory Concentrations; MMC: Minimum Microbicidal Concentrations; DSEtOH = D. senegambiensis EtOH extract; DSEtOAc = D. senegambiensis EtOAc extract; DSBuOH = D. senegambiensis n-BuOH extract; AMEtOH = A. monticola EtOH extract; AMEtOAc = A. monticola EtOAc extract; 3: ursolic acid; 4: sitosterol 3-O-β-D-glucopyranoside; 5: vitexin; 6: trans-tilliroside; 7: 3,4′-di-O-methylellagic acid; 8: dimethyl 4,4′,5,5′,6,6′-hexahydroxybiphenyl-2,2′-dicarboxylate; 9: lupeol; 10: ellagic acid; 12: 3-O-methylellagic acid 4′-O-β-D-xylopyranoside; 13: oleanolic acid
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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