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Table 3 Hematological parameters of female rats in chronic toxicity test

From: Acute and chronic toxicity of a polyherbal preparation – Jueyin granules

Treaments

Time

Control

JYG-H

JYG-M

JYG-L

7.5 g/kg

3.75 g/kg

1.875 g/kg

WBC

3 month

3.99 ± 1.44

3.46 ± 0.58

3.81 ± 0.49

4.04 ± 2.26

(× 109/L)

6 month

2.41 ± 1.31

1.95 ± 0.42

2.00 ± 0.79

1.90 ± 0.32

 

1 month recovery

4.58 ± 1.82

4.86 ± 1.96

4.42 ± 2.22

4.43 ± 0.88

RBC

3 month

7.99 ± 0.42

7.38 ± 0.28*

7.84 ± 0.29

7.91 ± 0.48

(× 1012/L)

6 month

7.55 ± 1.19

7.71 ± 0.25

7.84 ± 0.52

8.03 ± 0.42

 

1 month recovery

8.60 ± 0.35

8.35 ± 0.79

8.57 ± 0.44

8.41 ± 0.28

HGB

3 month

15.26 ± 0.61

14.40 ± 0.44*

14.86 ± 0.54

15.24 ± 0.86

(g/L)

6 month

14.30 ± 2.11

14.66 ± 0.89

14.64 ± 0.82

15.00 ± 0.43

 

1 month recovery

15.24 ± 0.85

15.24 ± 0.68

15.50 ± 0.88

14.86 ± 0.60

PLT

3 month

1264 ± 54

1254 ± 210

1196 ± 106

1207 ± 172

(× 109/L)

6 month

1209 ± 347

1099 ± 120

1128 ± 110

1109 ± 156

 

1 month recovery

1195 ± 140

1210 ± 198

1179 ± 98

1137 ± 121

NEUT

3 month

0.91 ± 0.62

0.98 ± 0.15

0.91 ± 0.13

0.94 ± 0.54

(× 109/L)

6 month

0.84 ± 0.57

0.66 ± 0.24

0.58 ± 0.16

0.58 ± 0.14

 

1 month recovery

1.45 ± 0.58

1.65 ± 0.59

1.13 ± 0.65

1.30 ± 0.30

LYMPH

3 month

2.67 ± 1.08

2.15 ± 0.52

2.57 ± 0.40

2.77 ± 1.55

(× 109/L)

6 month

1.14 ± 0.47

1.10 ± 0.25

1.17 ± 0.54

1.11 ± 0.22

 

1 month recovery

2.72 ± 1.28

2.75 ± 1.55

2.76 ± 1.57

2.69 ± 0.78

MONO

3 month

0.19 ± 0.10

0.22 ± 0.08

0.18 ± 0.07

0.20 ± 0.13

(× 109/L)

6 month

0.14 ± 0.13

0.09 ± 0.04

0.13 ± 0.13

0.11 ± 0.05

 

1 month recovery

0.18 ± 0.12

0.23 ± 0.15

0.19 ± 0.15

0.22 ± 0.14

  1. JYG-H, JYG-M,JYG-L Jueyin granules high-dose, medium dose, low-dose group, respectively. WBC total white blood cell count, RBC red blood cell, HGB hemoglobin, PLT blood platelet, Neut neutrophil, Lymph lymphocyte, Mono mononucleosis. The values are expressed as mean ± SEM (n = 10 rats for 3 months; n = 17–19 rats for 6 months; n = 10 rats for 1 month recovery). * Significantly different from control group (p < 0.05)