Table 2 Cytotoxicity of the crude extract, aqueous alkaloid-enriched fraction and solamargine as described by their IC₅₀ values in a panel of cancerous and non-cancerous cell lines

Extract/fraction^a

A2780

Caco-2

DU-145

HepG2

MCF-7

MDA-MB-231

SH-SY5Y

SK-Br3

3 T3-L1

C2C12

EA.hy.926

SC-1

Crude 24 h^a

34.73 ± 1.07

36.46 ± 1.20

74.33 ± 1.14

9.44 ± 1.11

44.35 ± 1.06

26.87*

19.10 ± 1.07

33.25 ± 1.10

37.24 ± 1.34

93.41 ± 1.08

3.88 ±

1.07

28.73 ± 1.09

Crude 72 h^a

32.88*

24.40 ± 1.13

47.11 ± 1.18

7.04 ± 1.08

27.94 ± 1.11

24.00*

12.97 ± 1.07

20.11 ± 1.08

19.55 ± 1.23

91.18 ± 1.13

2.79 ±

1.55

23.07 ± 1.10

Aqueous 24 h^a

31.45*

50.37 ± 1.26

46.53 ± 1.21

40.02 ± 1.08

31.91 ± 1.06

28.05*

29.11 ± *

29.24*

21.95 ± 1.50

>  100

16.45

± 1.06

19.89 ± 1.09

Aqueous 72 h^a

29.81*

25.21 ± 1.12

34.08*

20.66 ± 1.10

25.49 ± 1.13

26.11*

17.21 ± 1.15

18.81 ± 1.14

12.89 ± 1.23

62.00 ± 1.22

9.35 ±

1.08

21.10 ± 1.08

Solamargine 72 h^b

X

X

X

X

X

X

15.62 ± 1.45

18.59 ± 1.13

X

20.25 ± 1.08

8.30 ±

1.12

X

 Verapamil 24 h^b

93.48 ± 1.05

>  100

>  100

18.72 ± 1.08

>  100

>  100

>  100

>  100

>  100

>  100

31.55 ± 1.12

>  100

 Verapamil 72 h^b

65.75 ± 1.06

>  100

>  100

8.34 ± 1.08

46.76 ± 1.14

47.5 ± 1.09

>  100

41.92 ± 1.09

79.22 ± 1.21

>  100

5.69 ±

1.11

60.01 ± 1.16