Skip to main content

Table 5 Modulation of caspase (-8, -9, -3/7) activity and ATP levels in LPS-stimulated and 72 h WRE-treated THP-1 cells

From: Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)

WRE (mg/ml)

Caspase-8 (RLU ×  105)

Caspase-9 (RLU ×  105)

Caspase-3/7 (RLU ×  105)

ATP (RLU ×  105)

Control

0.991 ± 0.0001

5.738 ± 0.002

7.463 ± 0.012

4.332 ± 0.002

0.05

0.978 ± 0.0001 ***

5.562 ± 0.009 ***

6.919 ± 0.003 ***

4.133 ± 0.005 ***

0.1

1.216 ± 0.001 ***

7.045 ± 0.005 ***

8.211 ± 0.002 ***

4.889 ± 0.005 ***

0.2

1.095 ± 0.001 ***

6.091 ± 0.001 ***

7.532 ± 0.006 ***

4.576 ± 0.004 ***

0.4

0.952 ± 0.0003 ***

5.639 ± 0.003 ***

6.626 ± 0.007 ***

4.039 ± 0.0003 ***

  1. (Values expressed as mean ± SD, *** p < 0.0001 compared to the control)
Back to article page

BMC Complementary Medicine and Therapies

ISSN: 2662-7671

Contact us