Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)

Table 4 Modulation of caspase (-8, -9, -3/7) activity and ATP levels in LPS stimulated and 72 h W_RE treated PBMC’s

W_RE (mg/ml)	Caspase-8 (RLU × 10⁵)	Caspase-9 (RLU × 10⁵)	Caspase-3/7 (RLU × 10⁵)	ATP (RLU × 10⁵)
Control	42.651 ± 0.039	115.041 ± 3.848	155.556 ± 0.387	20.574 ± 0.316
0.05	53.840 ± 0.026 ^***	143.861 ± 3.929 ^***	196.471 ± 0.338 ^***	10.223 ± 0.046 ^***
0.1	52.109 ± 0.009 ^***	129.033 ± 0.289 ^***	192.695 ± 0.233 ^***	12.506 ± 0.373 ^***
0.2	42.751 ± 0.039 ^**	105.494 ± 4.247 ^**	154.203 ± 0.224 ^***	13.210 ± 0.043 ^***
0.4	29.656 ± 0.007 ^***	92.718 ± 0.021 ^***	165.139 ± 0.096 ^***	13.361 ± 0.279 ^***

(Values expressed as mean ± SD,^** p < 0.005, ^*** p < 0.0001 compared to the control)

ISSN: 2662-7671