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Table 3 Modulation of caspase (-8, -9, -3/7) activity and ATP levels in LPS stimulated and 24 h WRE treated THP-1 cells

From: Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)

WRE (mg/ml)

Caspase-8 (RLU ×  105)

Caspase-9 (RLU ×  105)

Caspase-3/7 (RLU ×  105)

ATP (RLU ×  105)

Control

10.207 ± 0.011

1.040 ± 0.007

1.251 ± 0.016

2.636 ± 0.011

0.05

8.440 ± 0.039 ***

2.365 ± 0.005 ***

1.315 ± 0.005 ***

3.726 ± 0.005 ***

0.1

2.413 ± 0.005 ***

2.459 ± 0.002 ***

2.294 ± 0.006 ***

5.132 ± 0.014 ***

0.2

7.149 ± 0.027 ***

0.775 ± 0.002 ***

3.406 ± 0.006 ***

29.838 ± 0.186 ***

0.4

2.456 ± 0.033 ***

3.197 ± 0.0001 ***

9.428 ± 0.004 ***

10.282 ± 0.195 ***

  1. (Values expressed as mean ± SD, *** p < 0.0001 compared to the control)