Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)

Table 2 Modulation of caspase (-8, -9, -3/7) activity and ATP levels in LPS stimulated and 24 h W_RE treated PBMC’s

W_RE (mg/ml)	Caspase-8 (RLU × 10⁵)	Caspase-9 (RLU × 10⁵)	Caspase-3/7 (RLU × 10⁵)	ATP (RLU × 10⁵)
Control	0.185 ± 0.006	0.366 ± 0.0003	7.756 ± 0.006	4.714 ± 0.004
0.05	0.155 ± 0.0002 ^***	0.376 ± 0.001 ^***	8.109 ± 0.094 ^**	2.783 ± 0.017 ^***
0.1	0.192 ± 0.00002	0.253 ± 0.0002 ^***	11.504 ± 0.253 ^***	5.208 ± 0.005 ^***
0.2	0.246 ± 0.0003 ^***	0.397 ± 0.0005 ^***	8.961 ± 0.015 ^***	3.741 ± 0.033 ^***
0.4	4.814 ± 0.006 ^***	0.351 ± 0.001 ^***	17.095 ± 0.089 ^***	6.965 ± 0.039 ^***

(Values expressed as mean ± SD, ^** p < 0.005, ^*** p < 0.0001 compared to the control)

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