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Table 1 Glutathione levels in LPS stimulated and WRE treated PBMC’s and THP-1 cells

From: Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)

Glutathione (μM)

WRE (mg/ml)

24 h Treatment

72 h Treatment

 

PBMC

THP-1

PBMC

THP-1

Control

1.613 ± 0.017

1.632 ± 0.004

4.799 ± 0.008

1.608 ± 0.004

0.05

1.442 ± 0.024 ***

1.267 ± 0.004 ***

5.232 ± 0.011 ***

1.548 ± 0.002 ***

0.1

1.617 ± 0.002

2.045 ± 0.002 ***

4.015 ± 0.001 ***

1.589 ± 0.004 ***

0.2

1.390 ± 0.001 ***

3.253 ± 0.017 ***

2.323 ± 0.005 ***

1.401 ± 0.006 ***

0.4

1.321 ± 0.006 ***

2.785 ± 0.005 ***

4.697 ± 0.003 ***

1.411 ± 0.005 ***

  1. (Values expressed as mean ± SD, *** p < 0.0001, compared to the control)