Fig. 1From: Total Saikosaponins of Bupleurum yinchowense reduces depressive, anxiety-like behavior and increases synaptic proteins expression in chronic corticosterine-treated miceThe schematic representation of experiment 2 design. Male C57BL/6Â J mice were divided 4 groups: Control, CORT, Citalopram (10Â mg/kg) and TSS (25Â mg/kg). Vehicle and corticosterone were delivered for 5Â weeks and continued through the behavior testing period. After 3 weeks of drug-free exposure to CORT administration, TSS and citalopram were given intragastrically once a day for 2Â weeks and continued through the behavior testing period. OFT, EPM, NSFT and FST were performed. After behavior tests, the mice were sacrificed for western blot essay or immunohistochemistry analysisBack to article page