Fig. 6

Proposed mechanism of açaí in breast cancer. In the breast tumor microenvironment, the macrophages are essential promoting the angiogenesis process and inflammation because they lead to increases in the VEGF, VEGFR-2, COX-2 and PGE2 levels. Açaí acts in this pathway and reduces the number of activated macrophages resulting in the decrease of the signaling pathways and the levels of these genes, suppressing growth or reducing the size of breast tumor