The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins

Table 2 Inhibitory effect of indomethacin on urinary electrolyte excretion induced by EFPA in rats

Groups	Urinary concentrations (mEq/L)
Groups	Na⁺	Cl⁻	K⁺	Ca²⁺
Control	70.50 ± 6.05	81.20 ± 3.10	52.20 ± 2.01	1.80 ± 0.10
EFPA (10 mg/kg)	90.00 ± 4.70^*	97.33 ± 2.90^*	36.70 ± 1.63^*	1.73 ± 0.10
EFPA (10 mg/kg) + Indomethacin (5 mg/kg)	43.50 ± 4.43^*,#	96.70 ± 4.10^*	61.00 ± 2.42^*,#	3.10 ± 0.20

Rats were treated over a 24 h period with a single dose of vehicle (control group), EFPA (10 mg/kg) or EFPA (10 mg/kg) + indomethacin (5 mg/kg, 1 h pretreatment) administered i.p. Data are given as means ± SEM of 6 different experiments. Statistical analyses were assessed using two-way analysis of variance (ANOVA) followed by Bonferroni’s post- test. *p < 0.05 versus control, and ^#p < 0.05 versus EFPA

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