Skip to main content


    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

  • Published:

Prevalence and correlates of herbal medicine use among type 2 diabetic patients in Teaching Hospital in Ethiopia: a cross-sectional study



Type 2 Diabetes Mellitus (T2DM) patients are increasingly using herbal remedies due to the fact that sticking to the therapeutic regimens is becoming awkward. However, studies towards herbal medicine use by diabetic patients is scarce in Ethiopia. Therefore, the aim of the current study was to explore the prevalence and correlates of herbal medicine use with different sociodemographic variables among type 2 diabetes patients visiting the diabetic follow-up clinic of University of Gondar comprehensive specialized hospital (UOGCSH), Ethiopia.


A hospital-based cross sectional study was employed on 387 T2DM patients visiting the diabetes illness follow-up care clinic of UOGCSH from October 1 to November 30, 2016. An interviewer-administered questionnaire regarding the demographic and disease characteristics as well as herbal medicine use was completed by the study subjects. Descriptive, univariate and multivariate logistic regression statistics were performed to determine prevalence and come up with correlates of herbal medicine use.


From 387 participants, 62% were reported to be herbal medicine users. The most prevalent herbal preparations used were Garlic (Allium sativum L.) (41.7%), Giesilla (Caylusea abyssinica (fresen.) (39.6%), Tinjute (Otostegia integrifolia Benth) (27.2%), and Kosso (Hagenia abyssinicaa) (26.9%). Most of herbal medicine users (87.1%) didn’t consult their physicians about their herbal medicine use. Families and friends (51.9%) were the frontline sources of information about herbal medicine followed by other DM patients who used herbal medicines (28.9%).


The present study revealed a high rate of herbal medicine use along with a very low rate use disclosure to the health care professionals. Higher educational status, a family history of DM, duration of T2DM and presence of DM complications were identified to be strong predictors of herbal medicine use. From the stand point of high prevalence and low disclosure rate, it is imperative for health care providers to strongly consult patients regarding herbal medicine use.


Diabetes mellitus (DM) is a chronic devastating disease. Despite the recent advances in care and management, still precipitates considerable morbidity and long term complications [1]. It’s a progressing chronic illness with anticipated global prevalence of more than 3 million by the year 2030 [2]. In Ethiopia, the number of patients living with diabetes is increasing alarmingly with a national prevalence near to be 6.5% [3]. Although insulin therapy is considered to be the corner stone in managing DM, treating diabetes remained as a challenge requiring considerable commitment to a life-long regimen imposed by the disease. Due to the chronicity of the disease and the need for life long therapy, several DM patients look for other alternative managements like using traditional herbal remedies [4,5,6,7,8,9,10,11,12].

According to World Health Organization (WHO), traditional medicine is defined as “health practices, approaches, knowledge and beliefs incorporating plant, animal and mineral based medicines, spiritual therapies, manual techniques and exercises, applied singularly or in combination to treat, diagnose and prevent illnesses and maintain well-being” [13]. Among the traditional medicine practices, the use of herbal medicines is the most popular and used by the general population and patients with chronic illnesses such as DM [14]. Patients with diabetes may prefer to use herbal remedies over modern medicine for a number of reasons including; dissatisfaction with the conventional treatment, treatment related adverse effects and the perceived suitability of herbal remedies with patients’ values and spiritual beliefs [8, 10, 12]. Recent literature reviews showed that prevalence of herbal remedies usage and other complementary therapies among DM patients varied immensely across different countries ranging from 15 to 75% [4].

In Ethiopia, the use of traditional herbal medicine has not been only common rather it’s also culturally acknowledged [15]. Nevertheless, the use of traditional herbal medicine in the general population and patients with chronic medical conditions like cancer and hypertension was well studied across different regions of Ethiopia [15,16,17], literatures on the prevalence and correlates of herbal medicine use among Ethiopian diabetes patients is lacking. Therefore, the present study was aimed to investigate the prevalence and factors associated with herbal medicine use among T2DM patients who attended the diabetes illness follow-up care clinic of UOGCSH, Gondar, Ethiopia.


Study design and setting

An institutional based cross-sectional study was underwent on 387 T2DM patients who visited the diabetes illness follow-up care clinic of UOGCSH from October 1 to November 30, 2016. UOGCSH is located in Gondar town, northwestern Ethiopia, 738 km away from the capital city of Ethiopia. It is the only referral hospital in the area with multiple specialty clinics such as Diabetes illness follow-up care clinic, which currently provides free service for more than 10,000 DM patients on outpatient level.

Sampling and recruitment strategies

All ≥18 years old adult patients diagnosed with T2DM for at least 1 year prior to recruitment were taken as our source populations, while those patients who visited diabetes illness follow-up care clinic of UOGCSH to check blood sugar and refill medications during the data collection period were considered as a study population. Single population proportion formula was used with the assumption of 95% confidence interval, 5% margin of error, 72.3% prevalence [15,16,17] of herbal medicine use and 5% contingency for possible non-respondents. Considering the above points, the final sample size was determined to be 408. As to UOGCSH statistics and information office record, an estimated number of 25 T2DM patients visit the diabetes illness follow-up care clinic every day for blood sugar checkup and medication refill. Thus, the total number of T2DM patients who will come to the clinic during the two-month study period was calculated. The number of participants to be interviewed per day during the 60 days of data collection was estimated to be 7.

Systematic random sampling technique was employed to recruit the study subjects. With this, the number of patient who visited the clinic every day were divided to the number of participants to be surveyed per day so that every fourth T2DM patients available at the diabetes illness follow-up care clinic during the 2-month data collection period were included. We chose the 2-month follow-up period for data collection to avoid duplication of the cases as patients return to the clinic every 2 months.

Survey instrument

Five nurses were trained to carefully collect the data through interviewer-administered questionnaire. Those collectors were properly trained on the instrument and ways of approaching the patients. The questionnaire was prepared via appropriate modification of items in previously used instruments regarding herbal medicine use by T2DM patients [12, 16, 17] and items were thoroughly reviewed for relevance by all the authors. The questionnaire, first prepared in English, was then translated to Amharic language (local language) and back to English so as to ensure that the translated version gives the proper meaning. Furthermore, a pretest was done on 20 T2DM patients, who were not included in the final analysis, and relevant modifications were instituted to the tool before the commencement of the gross data collection. Generally, the questionnaire included two main parts. Part one includes questions about the socio-demographic variables such as age, sex, marital status, educational level, age at diagnosis, as well as and disease related characteristics such as duration of the disease, family history of DM, and presence of DM complications. The second section aimed at assessing herbal medicine use, information source and discussion with health care providers about herbal medicine use. The use of herbal medicine among respondents was assessed by a series of questions including use of herbal medicines, type of herbal medicine used, purpose of use, source of information and any untoward effects encountered while using herbal medicines. Study subjects were labeled as herbal medicine users if they have taken herbal medicine(s) via any route of administration. Routine meal preparations and those that are taken as nutrients (vitamin supplements) were excluded. The survey instrument, along with a cover letter, is provided in Additional file 1.

Statistical analysis

The data collected were entered into and analyzed using Statistical Package for the Social Sciences (SPSS) software version 21.0 for Windows (SPSS Inc., Chicago, IL). Frequencies and percentages were used to express different variables. Pearson’s chi-square test was employed to compare baseline characteristics of herbal medicine users and non-users. Initially, Univariate analysis was done and variables with p-value less than 0.25 were further taken to the multivariate logistic regression analysis for proper adjustment with the possible confounders. Odds ratio (OR) with 95% confidence interval (95% CI) were clearly written along with corresponding p-value (p < 0.05) as cut off points for declaring statistical significance.


Out of 408 T2DM patients assumed for study participation, 387 completed the survey resulting in a 94.8% response rate. More than half of the patients (57.4%) were female with a mean age of 52.5 ± 12.6 years. Majority of the respondents were Orthodox Christians (54%) and married (68%). The socio-demographic and disease characteristics of study participants are summarized in Table 1.

Table 1 Patient characteristics and factors associated with herbal medicine use, Gondar, Ethiopia (N = 387)

Around 240 (62%) respondents claimed as they used traditional herbal medicine while 147 (38%) were found to be non-users. The most commonly used herbal preparations were Garlic (Allium sativum L.) (41.7%), Giesilla (Caylusea abyssinica (fresen.) (39.6%), Tinjute (Otostegia integrifolia Benth) (27.2%) and Kosso (Hagenia abyssinicaa) (26.9%). Plant-based traditional medicines relevant for the treatment and management of diabetes among respondents are summarized in Table 2. Table 3 describes the characteristics of herbal medicine use among respondents.

Table 2 Plant-based traditional medicines relevant for the treatment and management of diabetes among respondents, Gondar, Ethiopia (N = 387)
Table 3 Prevalence and characteristics of herbal medicine use in the study population, Gondar, Ethiopia (N = 387)

According to the current study, families and friends (51.9%) were the frontline sources of information about herbal medicine followed by other DM patients who used herbal medicines (28.9%) (Fig. 1). Dissatisfaction with the modern therapy (28.9%) and beliefs in merits of herbal medicines (25.1%) were the key reasons for herbal medicine use, while afraid of side effect (40%) and lack of belief in the benefits of herbal medicines (23%) were reported to be the major reasons for not using herbal medicines among non-users. Large proportions (87.1%) of herbal medicine users did not inform their use with health care providers due to anticipation of negative reply towards herbal medicine use (65.8%). Details of characteristics of herbal medicine use is presented in Table 3.

Fig. 1

Source of herbal medicine use among users, Gondar, Ethiopia

As to the analysis performed, statistically significant differences in marital status, educational status, average monthly income, presence of DM complications, family history of DM and duration of DM were found between herbal medicine users and non-users (Table 1). Variables that were significantly associated with herbal medicine use in the bivariate analysis were further examined in multivariate regression. Accordingly, educational status, presence of DM complications, a family history and duration of DM remained to be significant in the multivariate analysis. The odds of herbal medicine use in patients with tertiary education were 1.72 times higher compared to patients with primary or lower education. The odds of herbal medicine use among patients with > 6 years duration of T2DM were 1.51 times higher compared to patients with < 6 years duration of T2DM. The odds of herbal medicine use among patients who develop DM complications were 1.45 times higher than in patients without DM complications and the odds of herbal medicine use among patients with a positive family history of the disease were 3.12 times higher than in patients without family history of the disease (Table 1).


Herbal medicine use is becoming a common practice both in developed and developing countries [5,6,7,8,9,10,11,12, 18, 19]. Patients with T2DM are increasingly using herbal remedies due to the resistance in sticking to the conventional therapies. In many Sub Saharan countries including Ethiopia, herbal medicine use is amplified by the presence of several traditional medicine practitioners. With this, the present study aimed at exploring the prevalence and correlates of herbal medicine use among T2DM patients who visited the diabetes illness follow-up care clinic of UOGCSH, Ethiopia.

According to the finding of present study, 62% of respondents used traditional herbal medicine. This result concurs with the study done in Tanzania [20]. The use of traditional herbal based medicine in Africa has been largely linked with cultural beliefs and advices from family as well as friends [21]. Patients usually use herbal remedies along with biomedical knowledge to improve the perceived value of their treatments [21]. The elevated prevalence of traditional herbal medicine use in our study can also be partially explained by the fact that Ethiopia is gifted with a rich and diverse flora that comprised a foundation for primary health care [22].

The traditional herbs recognized in this study are composed of numerous pharmacologically active compounds showing a variety of therapeutic effects. The most commonly claimed indications among T2DM patients include hypoglycemic and lipid lowering effect, anti-oxidative and anti-inflammatory effects. Furthermore, majority of herbs reported including Hagenia abyssinica [23], Aloe vera [24], Clausean anistaa [25], Otostegia integrifolia Benth [26] and Caylusea abyssinica [27] also had well-documented direct hypoglycemic effects or indirectly affecting glucose metabolism. Even though herbal products are shown to be effective in reducing the blood pressure [28], they contain toxic substances which could affect the health of the patient and render the conventional drugs ineffective. Despite their pertinent pharmacologic effects, majority of the identified herbs in this study also exhibit many untoward effects. For instance, Clausena anisataa (commonly known as Limche in Ethiopia) has tremendous potentially advantageous pharmacologic effects for T2DM patients including a hypoglycemic effect via inhibition of angiotensin-converting enzyme (ACE) [29]. However, it is also found to be linked with inhibition of reverse transcriptase inhibitors which have been used for the treatment of HIV/AIDS [30]. Similarly, Aloe vera, which is traditionally used for the treatment of burns and minor skin disorders, could end up with acute hepato-renal toxicity if ingested in huge amounts. Garlic, another important medicinal plant used by T2DM patients in our study, appears to exert numerous therapeutic effects through a number of mechanisms including inhibition of HMG-CoA reductase and platelet aggregation, increasing fibrinolytic activity, protecting against hematotoxins and stimulating insulin secretion. However, it has also been associated with serious allergic reactions, alterations in the menstrual cycle, nausea; sweating, hypoglycemia and interact with medicines such as HIV protease inhibitors (eg, saquinavir) [31, 32].

Hence, through understanding these important effects of herbs and promoting evidence-based discussions with patients, both conventional health care providers and local traditional medical practitioners may be capable ofIn our study, family members providing health care to T2DM patients in a more successful and patient-centered approach.

In multivariate analysis; higher educational status, a family history of DM, duration of T2DM and presence of DM complications were identified as a strong predictors of herbal medicine use. This finding supports a previous research outputs which reported an association of herbal medicine use with longer duration of diabetes and the presence of DM complications [4, 33]. Educational status was also shown to be the strong predictor of herbal medicine use which confirms the results of previous studies [10]. Patients with a higher educational status may be more likely to explore for other therapies and ways to muddle through with their disease state and treatment effects [34].

In our study, family members, friends and relatives were the common sources of information about herbal medicine. In contrast, medical practitioners were the least information source for herbal medicine use. Similar findings has been reported among other group of patients with chronic conditions in Ethiopia including cancer and hypertension, where the most prominent sources of information for herbal medicine and other types of complementary therapies were outside the medical scheme and included families, relatives and friends [16, 17]. To prevent the possible harm following herbal medicines use, health care professionals should emphasize safety issues to diabetes patients and make an effort to endow them with evidence-based information. Herbal medicine users in our study also rarely unveil their use to health care professionals [10], this is a burning issue which seeks particular attention. The major reason cited for not discussing with the doctor was due to forestalling negative response about herbal medicine use. This could be attributed to the fact that the general negative attitude of doctors to herbal medicine and their prominence on scientific evidence may discourage patients from sharing information about their herbal medicine use. The lack of communication between the health care provider and herbal medicine users may have a detrimental effect on patient health status as a result of toxic effect of herbs and their adverse interactions with the conventional treatments. They may also interfere negatively with glycemic control and cause untoward effects and additional complications [35].

Strength and limitation

This survey highlights an area of research where there is lack of literature in the country. Yet, the survey has some limitations that should be taken into account while interpreting the results. As the study was a descriptive cross-sectional survey conducted in only one referral hospital, caution should be exercised when generalizing to other regions in Ethiopia. Our use of an interviewer-administered questionnaire, which depends on honesty and faith of the respondents, could also affect the responses as it may have been subjected to respondent or recall bias. Even with the above limitations, this survey has significant implications for improving the rational and evidence-based use of traditionally claimed medicinal herbs. A larger-scale and multi centered study that includes more diverse participants is needed to provide more accurate findings. In addition, we suggest future researchers to conduct similarly by using multiple samples for a single study population so as to come with more accurate and representative findings.


The present study revealed a high rate of herbal medicine use along with a very low rate of disclosure to the health care providers. Commonly used herbs among T2DM patients were Garlic (Allium sativum L.), Giesilla (Caylusea abyssinica (fresen.), Tinjute (Otostegia integrifolia Benth), and Kosso (Hagenia abyssinicaa). Patients mainly depend on families and friends as a source of information about herbal medicines. From the stand point of high prevalence and low disclosure rate, health care providers should often consult patients regarding herbal medicine use. Furthermore, the commonly used herbal preparations should also be further studied to confirm their efficacy and safety.



Adjusted odds ratio


Confidence interval


Odds ratio


Statistical package for the social sciences


Type 2 diabetes mellitus


University of Gondar Comprehensive Specialized Hospital


United States dollar


World Health Organization


  1. 1.

    International Diabetes Federation (IDF). Diabetes Atlas. 6th ed. Brussels: International Diabetes Federation; 2009.

  2. 2.

    Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 2011;94(3):311–21.

  3. 3.

    Nshisso LD, Reese A, Gelaye B, Lemma S, Berhane Y, Williams MA. Prevalence of hypertension and diabetes among Ethiopian adults. Diabetes Metab Syndr. 2012;6:36–41.

  4. 4.

    Chang HY, Wallis M, Tiralongo E. Use of complementary and alternative medicine among people living with diabetes: literature review. J Adv Nurs. 2007;58(4):307.

  5. 5.

    Ching SM, Zakaria ZA, Paimin F, Jalalian M. Complementary alternative medicine use among patients with type 2 diabetes mellitus in the primary care setting: a cross-sectional study in Malaysia. BMC Complement Altern Med. 2013;13(1):148.

  6. 6.

    Chang HA, Wallis M, Tiralongo E. Use of complementary and alternative medicine among people with type 2 diabetes in Taiwan: a cross-sectional survey. Evid Based Complement Alternat Med. 2011;2010:1-8.

  7. 7.

    Ashraf R, Khan RA, Ashraf I. Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients. Pak J Pharm Sci. 2011;24:565-70.

  8. 8.

    Ceylan S, Azal O, Taşlipinar A, Türker T, Açikel CH, Gulec M. Complementary and alternative medicine use among Turkish diabetes patients. Complement Ther Med. 2009;17:78-83.

  9. 9.

    Kumar D, Bajaj S, Mehrotra R. Knowledge, attitude and practice of complementary and alternative medicines for diabetes. Public Health. 2006;120:705-11.

  10. 10.

    Bell RA, Suerken CK, Grzywacz JG, Lang W, Quandt SA, Arcury TA. Complementary and alternative medicine use among adults with diabetes in the United States. Altern Ther Health Med. 2006;12(5):16–22.

  11. 11.

    Hashempur MH, Heydari M, Mosavat SH, Heydari ST, Shams M. Complementary and alternative medicine use in Iranian patients with diabetes mellitus. J Integr Med. 2015;13(5):319–25.

  12. 12.

    Naja F, Mousa D, Alameddine M, Shoaib H, Itani L, Mourad Y. Prevalence and correlates of complementary and alternative medicine use among diabetic patients in Beirut, Lebanon: a cross-sectional study. BMC Complement Altern Med. 2014;14(1):185.

  13. 13.

    World Health Organization. Legal status of traditional medicine and complementary/alternative medicine: a world-wide review. Geneva: WHO; 2001.

  14. 14.

    World Health Organization. Traditional medicine. Fact sheet Number 134.

  15. 15.

    Wassie SM, Aragie LL, Taye BW, Mekonnen LB. Knowledge, attitude, and utilization of traditional medicine among the Communities of Merawi Town, Northwest Ethiopia: a cross-sectional study. Evid Based Complement Alternat Med. 2015;2015:138073–7.

  16. 16.

    Erku DA. Complementary and alternative medicine use and its association with quality of life among cancer patients receiving chemotherapy in Ethiopia: a cross-sectional study. Evid Based Complement Alternat Med. 2016;2016:2809875–8.

  17. 17.

    Erku DA, Mekuria AB. Prevalence and correlates of complementary and alternative medicine use among hypertensive patients in Gondar town, Ethiopia. Evid Based Complement Alternat Med. 2016;2016:6987636–7.

  18. 18.

    Ooi CP, Yassin Z, Hamid TA. Momordica charantia for type 2 diabetes mellitus. Cochrane Database Syst Rev. 2012;15;(8):CD007845.

  19. 19.

    Modak M, Dixit P, Londhe J, Ghaskadbi S, Paul A, Devasagayam T. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr. 2007;40:163–73.

  20. 20.

    Lunyera J, Wang D, Maro V, et al. Traditional medicine practices among community members with diabetes mellitus in northern Tanzania: an ethnomedical survey. BMC Complement Altern Med. 2016;16:282.

  21. 21.

    Coulter I, Willis E. The rise and rise of complementary and alternative medicine: a sociological perspective. Med J Aust. 2004;180(11):587–9.

  22. 22.

    Deribe K, Kassaye D, Amberbir A and Getachew B. A Historical Overview of Traditional Medicine Practices and Policy in Ethiopia. Ethiop J Health Dev. 2006;20(2):127-34.

  23. 23.

    Assefa B, Glatzel G, Buchmann C. Ethnomedicinal uses of Hagenia abyssinica (Bruce) J.F. Gmel. Among rural communities of Ethiopia. J Ethnobiol Ethnomed. 2010;6:20.

  24. 24.

    Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract. 1999;49(447):823–8.

  25. 25.

    Ojewole JA. Hypoglycaemic effect of Clausena anisata (Willd) hook methanolic root extract in rats. J Ethnopharmacol. 2002;81:231–7.

  26. 26.

    Shewamene Z, et al. Methanolic leaf extract of Otostegia integrifolia Benth reduces blood glucose levels in diabetic, glucose loaded and normal rodents. BMC Complement Altern Med. 2015;15:19.

  27. 27.

    Tamiru W, et al. Evaluation of the effects of 80% methanolic leaf extract of Caylusea abyssinica (fresen.) fisch. & Mey. on glucose handling in normal, glucose loaded and diabetic rodents. BMC Complement Altern Med. 2012;12:151.

  28. 28.

    Pilkington K, Stenhouse E, Kirkwood G, Richardson J. Diabetes and complementary therapy: mapping the evidence. Pract Diab Int. 2007;24:371–6.

  29. 29.

    Duncan AC, Jäger AK, van Staden J. Screening of Zulu medicinal plants for angiotensin converting enzyme (ACE) inhibitors. J Ethnopharmacol. 1999;68(1–3):63–70.

  30. 30.

    Ayisi NK, Nyadedzor C. Comparative in vitro effects of AZT and extracts of Ocimum gratissimum, Ficus polita, Clausena anisata, Alchornea cordifolia, and Elaeophorbia drupifera against HIV-1 and HIV-2 infections. Antivir Res. 2003;58(1):25–33.

  31. 31.

    Bhatti R, Singh K, Ishar M, Singh J. The effect of Allium sativum on ischemic preconditioning and ischemia reperfusion induced cardiac injury. Indian J Pharmacol. 2008;40:261–5.

  32. 32.

    Bayan L, Koulivand PH, Gorji A. Garlic: a review of potential therapeutic effects. Avicenna J Phytomed. 2014;4(1):1–14.

  33. 33.

    Khalaf AJ, Whitford DL. The use of complementary and alternative medicine by patients with diabetes mellitus in Bahrain: a cross-sectional study. BMC Complement Altern Med. 2010;10:35.

  34. 34.

    Reid R, Steel A, Wardle J, Trubody A, Adams J. Complementary medicine use by the Australian population: a critical mixed studies systematic review of utilization, perceptions and factors associated with use. BMC Complement Altern Med. 2016;16(1):176.

  35. 35.

    Barnes J. Quality, efficacy and safety of complementary medicines: fashions, facts and the future. Part II: efficacy and safety. Br J Clin Pharmacol. 2003;55(4):331–40.

  36. 36.

    Leone A, Fiorillo G, Criscuoli F, Ravasenghi S, Santagostini L, Fico G, Spadafranca A, Battezzati A, Schiraldi A, Pozzi F, di Lello S, Filippini S, Bertoli S. Nutritional characterization and phenolic profiling of Moringa oleifera leaves grown in Chad, Sahrawi refugee camps, and Haiti. Int J Mol Sci. 2015;16:18923–37.

  37. 37.

    Anwar F, Latif S, Ashraf M, Gilani AH. Moringa oleifera: a food plant with multiple medicinal uses. Phytother Res. 2007;21:17–25.

  38. 38.

    Kew science 2017. Plants of the world online: Hagenia abyssinica (Bruce) J.F.Gmel. Royal botanic gardens. Available at Accessed date: March 3, 2018

  39. 39.

    Low G, Rogers LJ, Brumley SP, Ehrlich D. Visual deficits and retinotoxicity caused by the naturally occurring anthelmintics, Embelia ribes and Hagenia abyssinica. Toxicol Appl Pharmacol. 1985;81:220–30.

  40. 40.

    Luyckx VA, Ballantine R, Claeys M, Cuyckens F, Van den Heuvel H, Cimanga RK, et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. Am J Kidney Dis. 2002;39(3):e13.

  41. 41.

    Eshun K, He Q. Aloe vera: a valuable ingredient for the food, pharmaceutical and cosmetic industries–a review. Crit Rev Food Sci Nutr. 2004;44(2):91–6.

  42. 42.

    Mahomoodally MF. Traditional medicines in Africa: an appraisal of ten potent African medicinal plants. Evid Based Complement Alternat Med. 2013;2013:617459.

  43. 43.

    Chen W, Van Wyk B-E, Vermaak I, Viljoen AM. Cape aloes—a review of the phytochemistry, pharmacology and commercialisation of aloe ferox. Phytochem Lett. 2012;5(1):1–12.

  44. 44.

    Radha MH and Laxmipriya NP. Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. J Tradit Complement Med. 2014;5(1):21-6. eCollection 2015 Jan.

  45. 45.

    Yakoob AT, Tajuddin NB, Mohammed Hussain MI, et al. Antioxidant and Hypoglycemic Activities of Clausena anisata (Willd.) Hook F. Ex Benth. Root Mediated Synthesized Silver Nanoparticles. Pharmacognosy J. 2016;8(6):579-86.

  46. 46.

    Adesina SK. The isolation and identification of anticonvulsant agents from Clausenia anisata and Afraegle paniculata. Fitoterapia. 1982;53(3):63. (0367-326X)

  47. 47.

    Ito C, Itoigawa M, Aizawa K, Yoshida K, Ruangrungsi N, Furukawa H. Gamma-lactone carbazoles from Clausena anisata. J Nat Prod. 2009;72:1202–4.

Download references


The author acknowledges the support of the school of Pharmacy, University of Gondar and diabetes illness follow-up care clinic of UOGCSH in facilitating the data collection process.


No financial support was gained to conduct the study.

Availability of data and materials

The materials and data of this study are available from the corresponding author upon request.

Author information

Contributes to conception and design: ABM, DAE, SAB, EL. Acquisition of data, or analysis and interpretation of data: DAE, AKN, DSA, HGT. All authors agreed to be accountable for all aspects of the work and all authors read and approved the final manuscript.

Correspondence to Abebe Basazn Mekuria.

Ethics declarations

Ethics approval and consent to participate

This study was approved by the ethical committee of University of Gondar. Written informed consent from the patients was also obtained before conducting this study. Participants’ information obtained was kept anonymous.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Additional file

Additional file 1:

Questionnaire used for the study. (DOCX 21 kb)

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark


  • Herbal medicine
  • Diabetes
  • Gondar
  • Ethiopia