Administered treatment | Initial pain latency | Pain latency at the indicated time points after administration | |||
---|---|---|---|---|---|
0 s | 30 min | 60 min | 90 min | 120 min | |
Normal Control/No treatment | 13 + 5.0 | 6.2 + 6.8 | 4.8 + 3.3 | 7.8 + 5.1 | 6.3 + 2.1 |
Morphine (10 mg/kg) | 8 + 2.3 | 27 + 3.0* | 23 + 7.8* | 25 + 6.4* | 26 + 2.6* |
CE | |||||
50 mg/kg | 7.6 + 3.2 | 7.8 + 4.1 | 11.8 + 7.5 | 12 + 9.3 | 8.6 + 6.2 |
100 mg/kg | 8.4 + 2.3 | 8.4 + 6.0 | 18.6 + 7.4 | 6.2 + 6 | 8.4 + 4.6 |
200 mg/kg | 10.6 + 3.0 | 8.4 + 5.0 | 15.6 + 11.1 | 10.8 + 10.7 | 12.6 + 6.3 |
AqF | |||||
50 mg/kg | 4.8 + 3.3 | 13.2 + 5.5 | 9.6 + 8.1 | 15.4 + 12.1 | 14.2 + 9.2 |
100 mg/kg | 5.4 + 2.4 | 16.2 + 5.6 | 17.2 + 8.5 | 9.8 + 5.5 | 18.4 + 8.2 |
200 mg/kg | 7.6 + 2.7 | 17.2 + 6.8 | 12 + 9.7 | 22.2 + 4.4* | 12.6 + 4.6 |
EAF | |||||
50 mg/kg | 7.6 + 2.1 | 15.2 + 7.7 | 8.8 + 5.5 | 6 + 3 | 10.2 + 6.5 |
100 mg/kg | 5.4 + 2.1 | 8 + 1.9 | 5.8 + 2.9 | 5 + 2.7 | 3 + 1.5 |
200 mg/kg | 6.2 + 3.5 | 15.2 + 2.7 | 8.8 + 2.8 | 6.2 + 2.9 | 8.4 + 2.5 |