Table 2 Inductive effects of gallic acid, acetylsalicylic acid and their combinations on the specific activities of hepatic phases I and II drug metabolizing enzymes in mice

Cyt P450 R (μmole of NADPH oxidized/min/mg protein)

0.183 ± 0.002

(100)

0.214 ± 0.014

(116.67)

0.231 ± 0.004^#

(126.26)

0.267 ± 0.009^§

(145.61)

0.291 ± 0.004^§€

(158.58)

0.306 ± 0.003^§ȣɛ

(166.86)

Cyt b5 R (μmole of NADH oxidized/min/mg protein)

2.030 ± 0.205

(100)

2.521 ± 0.197

(124.13)

3.001 ± 0.012^#

(147.81)

3.015 ± 0.184^#

(148.50)

3.510 ± 0.097^§€

(172.87)

3.508 ± 0.006^§

(172.75)

GST (μmole of CDNB-GSH conjugate formed/min/mg protein)

1.246 ± 0.02

(100)

1.742 ± 0.021

(139.80)

2.399 ± 0.176^#

(192.52)

2.641 ± 0.257^§

(211.96)

2.809 ± 0.167^§€

(225.43)

3.215 ± 0.150^§¥

(257.82)

DTD (μmole of DCPIP reduced/min/mg protein)

0.035 ± 0.002

(100)

0.043 ± 0.002

(121.36)

0.063 ± 0.003^§

(179.48)

0.083 ± 0.002^§

(236.46)

0.084 ± 0.001^§£

(241.88)

0.092 ± 0.002^§ȣɛ

(264.38)