Zanthoxylum armatum DC extracts from fruit, bark and leaf induce hypolipidemic and hypoglycemic effects in mice- in vivo and in vitro study

Table 5 The effect of extracts of Zanthoxylum armatum and standard drug Glibenclamide on serum urea and creatinine level in normal and diabetic mice

Groups	Urea (m mol/L)	Creatinine (μ mol/L)
Normal	5.16 ± 0.42	28.20 ± 1.82
Diabetic	17.70 ± 0.85*	37.38 ± 0.80**
Normal Zf treated	4.88 ± 0.33	29.55 ± 1.04
Diabetic Zf treated	12.10 ± 1.52*	34.30 ± 0.69**
Normal Zb treated	4.71 ± 0.45	29.52 ± 1.06
Diabetic Zb treated	12.95 ± 0.56*	34.5 ± 0.73**
Normal Zl treated	4.13 ± 0.27	29.55 ± 1.01
Diabetic Zl treated	13.70 ± 1.44*	32.03 ± 1.33 *
Diabetic Glibenclamide treated	17.70 ± 0.85*	32.87 ± 2.37*

Data represented as mean ± S.D. values of 6 animals each *p < 0.001, **p < 0.05 (One way ANOVA, Dunnet’s t-test, Graph pad prism software). Normal control was compared with normal control and extract treated. The Diabetic control was compared with diabetic extract treated and standard

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