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Fig. 3 | BMC Complementary and Alternative Medicine

Fig. 3

From: Immune-enhancing activity of C. militaris fermented with Pediococcus pentosaceus (GRC-ON89A) in CY-induced immunosuppressed model

Fig. 3

Effects of GRC-ON89A on the phagocytic activity of peritoneal macrophages in CY-treated mice. a Scheme summarizing the immunosuppressed murine model protocol. b Fluorescent microscopy images (left panel) of phagocytosis of primary peritoneal macrophages from CY-treated immunosuppressed groups. Cells (5 × 104 cells per well) were treated with DMSO vehicle (100μg/mL GRC and 100μg/mL GRC-ON89A). Quantification of fluorescent bead uptake by primary peritoneal macrophages from CY-treated immunosuppressed groups exposure to fluorescent beads for 24 h (right panel). One-way ANOVA was used for comparison of group means, followed by Dunnett’s t-test (## = p < 0.01, # = p < 0.05 vs GRC-CY group). c Effect of GRC-ON89A on primary peritoneal macrophage proliferation. The cell image (left panel) of primary peritoneal macrophages from CY-treated immunosuppressed model group after oral administration (D.W., 1% GRC and 1% GRC-ON89A). The cell proliferation rate was quantified for statistics analysis using Image J software (right panel). One-way ANOVA was used for comparison of group means, followed by Dunnett’s t-test (** = p < 0.01, * = p < 0.05 vs control-CY group). Each figure is representative of three independent experiments; Scale bars = 50 μm

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