Fig. 6

Fisetin treatment suppresses the tumor growth and tumor angiogenesis. a Representative images of the implanted tumors and vessels in the fisetin-treated and control mice monitored by a Philips HD11 ultrasound scanner equipped with an 11 MHz linear array transducer are shown in this figure. Yellow dotted line defined the tumor location. The red and blue color indicates flows toward and away from the ultrasound transductor of blood vessels and microvessel density deduced from the ultrasound signals from randomly chosen planes indicates that fisetin/fisetin micelles treatment affects the tumor blood vessel characteristics in SKOV3 ovarian tumor xenografts. b Columns, means (n = 3); bars SE. c Representative images of random sections of the grafts from fisetin/fisetin micelles treated or control mice were labeled with marker for blood vessel marker CD31 and VEGFR2 and subjected to H&E staining (images were recorded at the magnification of × 200). Figures demonstrated that fisetin/fisetin micelles treatment compromises blood vessel network and VEGFR2 expression