Fig. 1

Fisetin and fisetin micelles inhibit tumor cell proliferation. a Chemical structure of fisetin, Chemical structure of mPEG-PCL copolymer and preparation scheme of fisetin micelles by the self-assembly method. b High performance liquid chromatography of fisetin and fisetin micelles. c Various cell lines were treated with30uM fisetin/fisetin micelles for different time periods (1 day to 4 days). Cell viability was detected by MTT assay. Fisetin does not have any inhibit effect on the survival of normal cell lines. Fisetin and fisetin micelles decreae cell viabilities of tumor derived cell lines such as HEC-1A, CASKi, HepG2. Dose-time-effect curves for fisetin and fisetin micelles on the SKOV3 cell line for 1, 3, 5 and 7 days and 10 μM,30 μM, 100 μM, 300 μM, Error bars represent standard error of the mean (SEM) (n = 3) *P < 0.05, vs. day 1 group; △p < 0.05, vs. control