Computational investigations of physicochemical, pharmacokinetic, toxicological properties and molecular docking of betulinic acid, a constituent of Corypha taliera (Roxb.) with Phospholipase A2 (PLA2)

Table 7 Absorption, distribution and metabolism of betulinic acid

Absorption
HIA (%)	P_Caco-2 (nm/s)		P_skin
96.00	21.86		−2.11
Distribution
PPB (%)	C_brain/C_blood	P-Glycoprotein (Inhibition)	P-Glycoprotein (Substrate)
100.00	8.20	Inhibitor	Substrate
Metabolism
Phase I		Phase II
Enzyme	Inhibitor/Substrate	Enzyme	Substrate/Non-substrate
Cytochrome P450 2C19 (Inhibitor)	Non	UDP-glucuronosyltransferase (UGT)	Non-substrate
Cytochrome P450 2C9 (Inhibitor)	Inhibitor	Sulfotransferase (SULT)	Non-substrate
Cytochrome P450 2D6 (Inhibitor)	Non
Cytochrome P450 2D6 (substrate)	Non
Cytochrome P450 3A4 ((Inhibitor)	Inhibitor
Cytochrome P450 3A4 (substrate)	Substrate

ISSN: 2662-7671