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Table 7 Absorption, distribution and metabolism of betulinic acid

From: Computational investigations of physicochemical, pharmacokinetic, toxicological properties and molecular docking of betulinic acid, a constituent of Corypha taliera (Roxb.) with Phospholipase A2 (PLA2)

Absorption
HIA (%) PCaco-2 (nm/s) Pskin
96.00 21.86 −2.11
Distribution
PPB (%) Cbrain/Cblood P-Glycoprotein (Inhibition) P-Glycoprotein (Substrate)
100.00 8.20 Inhibitor Substrate
Metabolism
Phase I Phase II
Enzyme Inhibitor/Substrate Enzyme Substrate/Non-substrate
Cytochrome P450 2C19 (Inhibitor) Non UDP-glucuronosyltransferase (UGT) Non-substrate
Cytochrome P450 2C9 (Inhibitor) Inhibitor Sulfotransferase (SULT) Non-substrate
Cytochrome P450 2D6 (Inhibitor) Non   
Cytochrome P450 2D6 (substrate) Non   
Cytochrome P450 3A4 ((Inhibitor) Inhibitor   
Cytochrome P450 3A4 (substrate) Substrate