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Table 3 Effect of cisplatin (CP) and different treatments of AHE on lung tissue protein, oxidative stress markers and lipid peroxidation

From: Acacia hydaspica R. Parker ameliorates cisplatin induced oxidative stress, DNA damage and morphological alterations in rat pulmonary tissue

Group

Protein (μg/mg Tissue)

H2O2 (nM/min/mg Tissue)

Nitrite (content μM/ml)

MDA (nM/min/mg protein)

Control

1.722 ± 0.042b

2.192 ± 0.025b

44.59 ± 0.609b

3.66 ± 0.265b

CP

0.965 ± 0.072a

5.752 ± 0.081a

82.16 ± 1.531a

8.649 ± 0.403a

AHE lone

1.711 ± 0.056b

2.148 ± 0.034b

44.26 ± 0.385b

3.599 ± 0.245b

CP + AHE

1.237 ± 0.025a,b*,d**

4.498 ± 0.073a,b,d

68.14 ± 0.81a,b,d

6.965 ± 0.214a,b**,d

AHE + CP

1.582 ± 0.040b,c**

3.049 ± 0.136a,b,c

50.53 ± 0.410a**,b,c

4.614 ± 0.184b,c

CP + Sily

1.591 ± 0.075b

2.99 ± 0.012a,b

50.03 ± 1.149a*,b

4.396 ± 0.208b

  1. Values expressed as mean ± SEM. a: Significance at p < 0.0001 Vs. control group, b: Significance at p < 0.0001 Vs. Cisplatin (CP) group. c: Significance at p < 0.0001 of AHE + CP pre-treated group Vs. CP + AHE post-treated group. d: Significance at p < 0.0001 of CP + AHE treatment groups Vs CP + Sily group. *, **: Significant difference at p < 0.05 and p < 0.001 respectively. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters (One way ANOVA followed by Tukey’s multiple comparison tests)