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Table 1 Results of the bacterial reverse mutation test for SOCG

From: Genotoxicity evaluation of So-ochim-tang-gamibang (SOCG), a herbal medicine

  TA98 TA100 TA1535 TA1537 WP2uvrA (pKM101)
Dose (μg/plate) Number of revertant colonies/plate (in the absence of metabolic activation)d [factor]e
Negative controla 19 ± 3 52 ± 4 6 ± 2 5 ± 2 86 ± 4
313 20 ± 1[1.05] 56 ± 13[1.08] 7 ± 2[1.17] 4 ± 2[0.80] 90 ± 12[1.05]
625 19 ± 4[1.00] 50 ± 7[0.96] 6 ± 2[1.00] 6 ± 3[1.20] 92 ± 6[1.07]
1250 19 ± 4[1.00] 49 ± 7[0.94] 6 ± 2[1.00] 6 ± 1[1.20] 100 ± 5[1.16]
2500 20 ± 3[1.05] 41 ± 8[0.79] 6 ± 1[1.00] 5 ± 1[1.00] 103 ± 6[1.20]
5000 19 ± 3[1.00] 28 ± 3[0.54] 6 ± 1[1.00] 4 ± 1[0.80] 107 ± 11[1.24]
Positive controlb 475 ± 80[25.0] 549 ± 29[10.6] 461 ± 28[76.8] 430 ± 160[86.0] 1056 ± 117[12.3]
Dose (μg/plate) Number of revertant colonies/plate (in the presence of metabolic activation)d [factor]e
Negative controla 22 ± 3 79 ± 6 9 ± 2 13 ± 2 114 ± 15
313 21 ± 3[0.95] 73 ± 7[0.92] 10 ± 3[1.11] 14 ± 3[1.08] 113 ± 8[0.99]
625 23 ± 3[1.05] 76 ± 4[0.96] 10 ± 2[1.11] 17 ± 3[1.31] 127 ± 17[1.11]
1250 22 ± 2[1.00] 76 ± 10[0.96] 9 ± 2[1.00] 13 ± 4[1.00] 141 ± 7[1.24]
2500 21 ± 5[0.95] 72 ± 10[0.91] 11 ± 4[1.22] 15 ± 3[1.15] 147 ± 9[12.9]
5000 20 ± 6[0.91] 75 ± 4[0.95] 10 ± 3[1.11] 13 ± 1[1.00] 146 ± 6[1.28]
Positive controlc 221 ± 10[10.0] 404 ± 4[5.11] 121 ± 18[13.4] 134 ± 9[10.3] 460 ± 28[4.04]
  1. aWater for injection
  2. bTA98: 2-Nitrofluorene (2-MF), 5.0 μg/plate; TA100: Sodium azide (SA), 1.5 μg/plate; TA1535: SA, 1.5 μg/plate; TA1537: 9-Aminoacridine (9-AA), 80 μg/plate; WP2uvrA(pKM101): 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide(AF2), 0.005 μg/plate
  3. cTA98: 2-Aminoanthracene (2-AA), 1.0 μg/plate; TA100: 2-AA, 2.0 μg/plate; TA1535: 2-AA, 3.0 μg/plate; TA1537: 2-AA, 3.0 μg/plate; WP2uvrA(pKM101): 2-AA, 2.0 μg/plate
  4. dData expressed as mean ± standard deviation
  5. eNo. of revertant colonies per treated plate/No. of revertant colonies per negative control plate