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Table 10 (A and B) Hematological parameters of the rats in acute and sub-acute oral toxicity tests

From: Acute and sub-acute oral toxicity of Dracaena cinnabari resin methanol extract in rats

A

Acute oral toxicity

Hematological Parameters

Sex

Control

DC 300 mg/kg

DC2000 mg/kg

 

P value

 HGB (g/L)

F (n = 3)

153.00 ± 10.00

145.50 ± 9.50

149.33 ± 17.95

 

0.789

 WBC (10^9/L)

F (n = 3)

6.83 ± 0.23

7.77 ± 0.38

8.05 ± 0.75

 

0.057

 Neutrophil (10^9/L)

F (n = 3)

0.55 ± 0.13

0.56 ± 0.07

0.58 ± 0.14

 

0.961

 Lymphocyte (10^9/L)

F (n = 3)

6.39 ± 0.87

6.72 ± 1.15

7.29 ± 0.52

 

0.498

 Monocyte (10^9/L)

F (n = 3)

0.14 ± 0.03

0.15 ± 0.02

0.18 ± 0.3

 

0.228

 Eosinophil (10^9/L)

F (n = 3)

0.08 ± 0.02

0.10 ± 0.02

0.11 ± 0.02

 

0.125

 Basophil (10^9/L)

F (n = 3)

0.02 ± 0.01

0.03 ± 0.02

0.03 ± 0.02

 

0.531

B

Sub-acute oral toxicity

Hematological Parameters

Sex

Control

DC 500 mg/kg

DC1000 mg/kg

DC1500 mg/kg

P value

 HGB (g/L)

M (n = 5)

149.40 ± 6.47

148.80 ± 5.40

150.40 ± 12.72

156.80 ± 12.91

0.575

F (n = 5)

156.40 ± 5.81

148.80 ± 7.82

150.60 ± 3.85

153.40 ± 5.81

0.243

 WBC (10^9/L)

M (n = 5)

9.22 ± 1.03

9.30 ± 2.45

9.46 ± 1.33

9.56 ± 3.67

0.996

F (n = 5)

6.86 ± 0.59

7.40 ± 1.15

7.38 ± 0.93

7.82 ± 0.81

0.431

 Neutrophil (10^9/L)

M (n = 5)

0.98 ± 0.12

1.01 ± 0.16

1.03 ± 0.18

1.14 ± 0.30

0.626

F (n = 5)

0.81 ± 0.21

0.77 ± 0.11

0.87 ± 0.17

0.89 ± 0.14

0.646

 Lymphocyte (10^9/L)

M (n = 5)

9.66 ± 2.12

9.64 ± 1.67

10.39 ± 1.99

10.77 ± 2.08

0.753

F (n = 5)

8.22 ± 1.07

8.44 ± 1.22

8.67 ± 1.00

9.20 ± 1.14

0.564

 Monocyte (10^9/L)

M (n = 5)

0.16 ± 0.02

0.15 ± 0.02

0.17 ± 0.04

0.19 ± 0.04

0.411

F (n = 5)

0.17 ± 0.03

0.16 ± 0.03

0.18 ± 0.02

0.18 ± 0.03

0.623

 Eosinophil (10^9/L)

M (n = 5)

0.08 ± 0.02

0.09 ± 0.02

0.10 ± 0.02

0.10 ± 0.03

0.388

F (n = 5)

0.08 ± 0.01

0.09 ± 0.02

0.07 ± 0.03

0.10 ± 0.02

0.215

 Basophil (10^9/L)

M (n = 5)

0.06 ± 0.2

0.04 ± 0.03

0.04 ± 0.03

0.04 ± 0.03

0.537

F (n = 5)

0.02 ± 0.02

0.03 ± 0.02

0.03 ± 0.02

0.04 ± 0.02

0.397

  1. Values expressed as a mean ± standard deviation. Sex (male, M and female, F)
  2. *p-value less than 0.05, (p < 0.05) significant value