Skip to main content

Advertisement

Table 4 Depressant effects of the methanol extract of the Baccaurea ramiflora pulp and seed on open field test in mice

From: Screening of Baccaurea ramiflora (Lour.) extracts for cytotoxic, analgesic, anti-inflammatory, neuropharmacological and antidiarrheal activities

Group Dose Number of Movements
0 min 30 min 60 min 90 min 120 min
Negative Control (1% tween 80 in water) 239.40 ± 2.60 189.6 ± 7.01 176.8 ± 2.42 159 ± 2.72 146 ± 2.34
Positive control (Diazepam) 1 mg/kg, 89 ± 1.84* 87.4 ± 1.347* 70 ± 1.92* 65 ± 1.78* 51 ± 1.88*
MEBRP 100 mg/kg 201 ± 2.62* 158 ± 3.22 76 ± 2.55* 68 ± 2.90* 51.6 ± 2.72*
MEBRP 200 mg/kg 180.8 ± 2.614* 148.2 ± 3.64* 66 ± 2.04* 52 ± 3.21* 42 ± 2.39*
MEBRS 100 mg/kg 206.8 ± 2.314* 170 ± 2.81 79 ± 2.454* 72.8 ± 3.05* 52.2 ± 2.95*
MEBRS 200 mg/kg 169 ± 3.783* 120 ± 5.05* 70 ± 4.742* 61 ± 3.55* 49.6 ± 2.04*
  1. Values are means ± S.E.M. of five mice (n = 5)
  2. *p < 0.05 considered as significant compared to control (Dunett’s test). Control animals received vehicle (1% Tween 80 in water), positive control mice received diazepam 1 mg/kg body weight, MEBRP and MEBRS treated groups were administered with 100 and 200 mg/kg body weight (p.o.), respectively