Screening of Baccaurea ramiflora (Lour.) extracts for cytotoxic, analgesic, anti-inflammatory, neuropharmacological and antidiarrheal activities

Table 4 Depressant effects of the methanol extract of the Baccaurea ramiflora pulp and seed on open field test in mice

Group	Dose	Number of Movements
Group	Dose	0 min	30 min	60 min	90 min	120 min
Negative Control (1% tween 80 in water)	–	239.40 ± 2.60	189.6 ± 7.01	176.8 ± 2.42	159 ± 2.72	146 ± 2.34
Positive control (Diazepam)	1 mg/kg,	89 ± 1.84^*	87.4 ± 1.347^*	70 ± 1.92^*	65 ± 1.78^*	51 ± 1.88^*
MEBRP	100 mg/kg	201 ± 2.62^*	158 ± 3.22	76 ± 2.55^*	68 ± 2.90^*	51.6 ± 2.72^*
MEBRP	200 mg/kg	180.8 ± 2.614^*	148.2 ± 3.64^*	66 ± 2.04^*	52 ± 3.21^*	42 ± 2.39^*
MEBRS	100 mg/kg	206.8 ± 2.314^*	170 ± 2.81	79 ± 2.454^*	72.8 ± 3.05^*	52.2 ± 2.95^*
MEBRS	200 mg/kg	169 ± 3.783^*	120 ± 5.05^*	70 ± 4.742^*	61 ± 3.55^*	49.6 ± 2.04^*

Values are means ± S.E.M. of five mice (n = 5)
^*p < 0.05 considered as significant compared to control (Dunett’s test). Control animals received vehicle (1% Tween 80 in water), positive control mice received diazepam 1 mg/kg body weight, MEBRP and MEBRS treated groups were administered with 100 and 200 mg/kg body weight (p.o.), respectively