Fig. 8
Pro-inflammatory mediator expression in CCl4-intoxicated mice. Mice were pretreated with the extract or methylprednisolone during 3 consecutive days. On the third day, acute liver injury was induced with carbon tetrachloride. Bar graphs present, Tumor Necrosis Factor alpha (a), Interleukin-1 beta (b), Interleukin-6 (c), and Cyclooxygenase-2 (d) liver expression in mice. Data are expressed as mean ± Standard Error of the Mean. Significant Dunn’s post tests are indicated as *p < 0.05; **p < 0.01; ***p < 0.001; ns: non-significant. The p-value indicates the Mann-Whitney test. One experiment conducted, n = 10 in each mice group. TNFα: Tumor Necrosis Factor alpha; IL1-β: Interleukin-1 beta; IL-6: Interleukin-6; COX-2: Cyclooxygenase-2; CCl4: Carbon tetrachloride; NVH: Neoboutonia velutina aqueous extract; MP: Methylprednisolone; GAPDH: Glyceraldehyde-3-Phosphate Dehydrogenase