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Fig. 7 | BMC Complementary and Alternative Medicine

Fig. 7

From: Neoboutonia melleri var velutina Prain: in vitro and in vivo hepatoprotective effects of the aqueous stem bark extract on acute hepatitis models

Fig. 7

Histological changes in CCl4-intoxicated mice. Animals were pretreated with NVH extract or methylprednisolone during 3 consecutive days. On the third day, acute liver injury was induced with CCl4. Mice were sacrificed 24 h after CCl4 injection. Liver sections were fixed and paraffin-embedded before haematoxylin-eosin staining. CTR: Control mice with a normal liver structure; CCl4: carbon tetrachloride-treated mice with a damaged liver; CCl4 + NVH (3, 15 and 75): carbon tetrachloride and extract-treated mice with regenerating areas at highest doses; CCl4 + MP: carbon tetrachloride and methylprednisolone treated mice with persistent lesions. NVH: Neoboutonia velutina aqueous extract; MP: Methylprednisolone; CCl4: Carbon tetrachloride; CV: Centrilobular vein; L: Necrotic area; RA: Regenerating area. HEx100

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