Skip to main content

Table 6 Effect of Doxorubicin (DOX) and different treatments of AHE on cardiac tissue protein, H2O2, nitrite content and lipid peroxidation

From: Acacia hydaspica R. Parker prevents doxorubicin-induced cardiac injury by attenuation of oxidative stress and structural Cardiomyocyte alterations in rats

Group

Protein (μg/mg Tissue)

H2O2 (nM/min/mg Tissue)

Nitrite (content μM/ml)

TBARS (nM/min/mg protein)

Control

1.638 ± 0.033b

1.932 ± 0.015b

42.59 ± 0.552b

2.874 ± 0.180b

DOX

1.122 ± 0.0323a

5.854 ± 0.011a

78.12 ± 0.499a

7.575 ± 0.573a

AHE alone

1.614 ± 0.015b

1.911 ± 0.049b

41.72 ± 0.650b

2.859 ± 0.086b

DOX + AHE (200)

1.392 ± 0.036a,b

3.950 ± 0.003a,b,d

66.47 ± 1.456a,b,d

6.159 ± 0.091a,b*,d

DOX + AHE (400)

1.490 ± 0.018a*,b

2.719 ± 0.006a,b,c

49.94 ± 0.770a,b,c

3.258 ± 0.167b,c

DOX + Sily

1.509 ± 0.027b

2.645 ± 0.004a,b

50.60 ± 0.322a,b

3.233 ± 0.151b

  1. Values expressed as mean ± SEM
  2. aSignificance at p < 0.0001 Vs. control group
  3. bSignificance at p < 0.0001 Vs. Doxorubicin (DOX) group
  4. cSignificance at p < 0.0001 of DOX + AHE 400 mg/kg group Vs. DOX + AHE 200 mg/kg group
  5. dSignificance at p < 0.0001 of AHE co-treatment groups Vs DOX + Sily group
  6. *Significant difference at p < 0.05 and p < 0.001 respectively. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters. (One way ANOVA followed by Tukey’s multiple comparison tests). Sily-Silymarin