Fig. 7
BP inhibits xenographic growth of BFTC cells in NOD-SCID mice. a Approximately 5 × 105 BFTC cells were injected into the dorsal subcutaneous tissue of NOD-SCID mice. When the tumor reached 100–250 mm3, BFTC tumor-bearing mice were administrated s.c. with vehicle control or 100 to 200 mg/kg BP on days 0–4 for 5 days. The relative tumor volumes of the control and the BP-treated groups are shown as means ± S.D. of tumor volume at each time point. b Tumor tissue sections with HE staining. The proliferation marker ki67 were immuno-histochemically identified in the control and the BP-treated groups. Expression of cleavaged caspase-3 in the BFTC xenograft tumor tissue was up-regulated after BP administration as compared to control group by western blotting analysis c